Table 1. TBUT in Eyes with Pterygium vs. Normal Controls.
TBUT was found to be significantly lower in patients with pterygium vs. controls in 21 of 28 studies. Eighteen studies reported TBUT as an average of three measurements, three studies reported TBUT as an average of less than three measurements, and seven studies did not specify the number of measurements used to determine TBUT.
| Year | Author | n = No. patients, No. eyes | Results | No. measurements |
|---|---|---|---|---|
| 2020 | Zhao et al.(12) | n = 35, 40 | 4.02 s lower in pterygium† | 2 |
| 2020 | Patkar et al.(13) | n = 100, 200 | 0.93 s lower in pterygium† | 1 |
| 2019 | Safarzadeh et al.(14) | n = 95, 190 | 4.50 s lower in pterygium† | 3 |
| 2019 | Wanzeler et al.(15) | n = 83, 83 | 0.73 s lower in pterygiumN | Not reported |
| 2019 | Gupta et al.(16) | n = 50, 100 | 2.08 s lower in pterygium† | 3 |
| 2019 | Li et al.(17) | n = 108, 108 | 3.03 s lower in pterygium†N | Not reported |
| 2018 | Küçük et al.(18) | n = 64, 96 | 5.40 s lower in pterygium†1 | 3 |
| 2017 | Ye et al.(19) | n = 80, 80 | 3.90 s lower in pterygium† | 3 |
| 2017 | Manhas et al.(20) | n = 270, 270 | 4.34 s lower in pterygium† | 3 |
| 2017 | Antony et al.(21) | n = 100, 200 | 3.60 s lower in pterygium† | Not reported |
| 2017 | Wu et al.(22) | n = 99, 99 | 2.90 s lower in pterygium†N | Not reported |
| 2014 | Ozsutcu et al.(23) | n = 65, 130 | 2.00 s lower in pterygium† | 3 |
| 2014 | Kampitak et al.(24) | n = 92, 184 | 5.80 s lower in pterygium† | Not reported |
| 2014 | Gonnermann et al.(25) | n = 40, 40 | 6.10 s lower in pterygium† | 1 |
| 2014 | Hashemi et al.(26) | n = 1008, 1008 | Lower in pterygium2 | 3 |
| 2013 | Roka et al.(3) | n = 228, 228 | 5.96 s lower in pterygium† | 3 |
| 2013 | Rajab et al.(28) | n = 110, 110 | 3.60 s lower in pterygium†3 | 3 |
| 2012 | Julio et al.(27) | n = 60, 60 | No difference | 3 |
| 2010 | Bandyopadhyay et al.(29) | n = 100, 100 | Lower in pterygium†2 | Not reported |
| 2009 | Lu et al.(30) | n = 2112, 2112 | Lower in pterygium†2 | 3 |
| 2006 | Lekhanont et al.(31) | n = 550, 550 | Lower in pterygium†2 | 3 |
| 2005 | Balogun et al.(6) | n = 221, 221 | 1.96 s lower in pterygium†4 | 3 |
| 2001 | Ishioka et al.(7) | n = 20, 40 | 3.30 s lower in pterygium† | 1 |
| 2001 | Ergin et al.(32) | n = 129, 202 | 1.38 s lower in pterygium | 3 |
| 1998 | Kadayifçilar et al.(33) | n = 140, 140 | 3.57 s lower in pterygium† | 3 |
| 1991 | Rajiv et al.(34) | n = 106, 106 | 4.80 s lower in pterygium5 | Not reported |
| 1984 | Pandey et al.(35) | n = 1400, 1763 | No difference6,2 | 3 |
| 1980 | Taylor et al.(36) | n = 30, 54 | Lower in pterygium2 | 3 |
†
Statistically significant
N
Average non-invasive tear break up time (NIBUTav)
1
Study included pingueculum only
2
Absolute values not reported
3
Study included pterygium and pingueculum; 3.60 s lower in pterygium, 3.90 s lower in pingueculum
4
Study included pterygium and pingueculum; 1.96 s lower in pterygium, 0.90 s higher in pingueculum
5
Statistical values not reported
6
Abnormal TBUT defined as < 30 s