Table 1.
Demographic characteristics, pertinent past medical history, and symptoms at enrollment of 512 subjects included for analysis by case control status.
| Control subjects (N = 306) | Classic definition of EoE with PPI trial (N = 149) | PPI-responsive esophageal eosinophilia (N = 57) | AGREE consensus definition of EoE (N = 206) | |
|---|---|---|---|---|
|
| ||||
| Demographic characteristics | ||||
|
| ||||
| Age – mean (SD) | 52.3 (14.3) | 37.9 (12.9) | 46.0 (13.8) | 40.1 (13.6) |
| Male – N (%) | 116 (37.9) | 90 (60.4) | 39 (68.4) | 129 (62.6) |
| Race:* Non-Hispanic White – N (%) | 243 (79.7) | 141 (94.6) | 51 (89.5) | 192 (93.2) |
| Black – N (%) | 50 (16.4) | 4 (2.7) | 4 (7.0) | 8 (3.9) |
| Hispanic White – N (%) | 5 (1.6) | 2 (1.3) | 1 (1.8) | 3 (1.5) |
| Native American – N (%) | 4 (1.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Multiple races – N (%) | 2 (0.7) | 1 (0.7) | 0 (0.0) | 1 (0.5) |
|
| ||||
| Past medical history | ||||
|
| ||||
| Any atopic disease† – N (%) | 171 (60.6) | 102 (72.3) | 38 (76.0) | 140 (73.3) |
| Food allergy‡ – N (%) | 47 (16.5) | 50 (35.2) | 12 (23.5) | 62 (32.1) |
| Endoscopic dilation – N (%) | 97 (31.7) | 53 (35.6) | 13 (22.8) | 66 (32.0) |
|
| ||||
| Symptoms | ||||
|
| ||||
| Dysphagia – N (%) | 224 (73.2) | 146 (98.0) | 54 (94.7) | 200 (97.1) |
| Gastroesophageal reflux symptoms – N (%) | 128 (41.8) | 18 (12.1) | 11 (19.3) | 29 (14.1) |
| Abdominal pain – N (%) | 32 (10.5) | 9 (6.0) | 3 (5.3) | 12 (5.8) |
| Nausea or vomiting – N (%) | 17 (5.6) | 3 (2.0) | 2 (3.5) | 5 (2.4) |
|
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| Endoscopy findings | ||||
|
| ||||
| Rings – N (%) | 38 (12.4) | 122 (81.9) | 30 (52.6) | 152 (73.8) |
| Furrows – N (%) | 20 (6.5) | 132 (88.6) | 27 (47.4) | 159 (77.2) |
| Edema/decreased vascular pattern – N (%) | 9 (2.9) | 73 (49.0) | 2 (3.5) | 75 (36.4) |
| White plaques – N (%) | 13 (4.2) | 72 (48.3) | 11 (19.3) | 83 (40.3) |
| Erythema§ – N (%) | 7 (2.3) | 1 (0.7) | 1 (1.8) | 2 (1.0) |
| Crepe paper – N (%) | 3 (1.0) | 11 (7.4) | 1 (1.8) | 12 (5.8) |
| Erosive esophagitis – N (%) | 46 (15.0) | 4 (2.7) | 6 (10.5) | 10 (4.9) |
| Erosions – N (%) | 10 (3.3) | 2 (1.3) | 0 (0.0) | 2 (1.0) |
| Stricture – N (%) | 56 (18.3) | 50 (33.6) | 9 (15.8) | 59 (28.6) |
| Diffuse narrowing – N (%) | 13 (4.2) | 48 (32.2) | 3 (5.3) | 51 (24.8) |
| Schatzki's ring – N (%) | 31 (10.1) | 11 (7.4) | 10 (17.5) | 21 (10.2) |
| Hiatus hernia – N (%) | 129 (42.2) | 21 (14.1) | 15 (26.3) | 36 (17.5) |
|
| ||||
| Histology findings | ||||
|
| ||||
| Peak overall eosinophil count – Mean (SD) | 2.9 (8.9) | 121.0 (110.0) | 65.6 (52.8) | 106.0 (101.0) |
| Peak overall eosinophil count – Range | 0.0 – 85.4 | 15.7 – 667.0 | 15.0 – 273.0 | 15.0 – 667.0 |
| Eosinophil degranulation| – N (%) | 34 (12.5) | 122 (94.6) | 22 (40.7) | 144 (78.7) |
| Eosinophil microabscess| – N (%) | 5 (1.8) | 88 (68.8) | 3 (5.6) | 91 (50.0) |
| Basal zone hyperplasia¶ – N (%) | 29 (11.0) | 61 (50.0) | 11 (20.4) | 72 (40.9) |
| Spongiosis** – N (%) | 80 (28.8) | 117 (88.6) | 19 (35.2) | 136 (73.1) |
| Lamina propria fibrosis†† – N (%) | 5 (6.3) | 33 (41.3) | 5 (19.2) | 38 (35.8) |
SD, standard deviation
*
1 missing
†
39 missing
‡
35 missing
§
2 missing
|
56 missing
¶
57 missing
**
48 missing
††
11 missing among 190 (37%) with evaluable lamina propria.