Table 2.

Multivariable adjusted case control odds ratios with 95% confidence limits and model fit and prediction statistics for cases defined by AGREE consensus definition for the predictive models built with factors available prior to diagnostic endoscopy, factors available at diagnostic endoscopy, and factors available after histology results.

	Factors available prior to diagnostic endoscopy	Factors available at diagnostic endoscopy	Factors available after histology results excluding eosinophil count	Factors available after histology results including eosinophil count
Age at biopsy (per year)	0.94 (0.93 – 0.96)	0.96 (0.94 – 0.97)	0.96 (0.94 – 0.98)	0.97 (0.94 – 1.00)
Male sex versus female	2.86 (1.80 – 4.55)	2.20 (1.29 – 3.76)	2.99 (1.56 – 5.72)
White race versus others	3.51 (1.76 – 7.04)
History of atopic condition or food allergy versus neither	1.72 (1.08 – 2.75)
Dysphagia at baseline	15.01 (6.12 – 36.83)	7.58 (2.7 – 21.27)	6.14 (2.03 – 18.53)	12.27 (1.37 – 110.01)
Rings, furrows, edema, white plaques, narrowing, or crepe paper appearance on endoscopy		20.69 (11.95 – 35.82)	9.74 (5.33 – 17.77)	5.55 (2.15 – 14.38)
Erosive esophagitis on endoscopy		0.28 (0.1 – 0.74)	0.36 (0.14 – 0.92)
Hiatus hernia on endoscopy		0.53 (0.29 – 0.97)
Eosinophil degranulation			3.80 (1.94 – 7.46)
Eosinophil microabscess			9.05 (3.08 – 26.55)
Overall peak eosinophil count (per additional ten eosinophils per HPF)				1.54 (1.12 – 1.22)
Model Akaike information criterion*	517.19	372.39	312.44	140.64
Area under the receiver-operator characteristic curve	0.84 (0.81 – 0.88)	0.92 (0.89 – 0.94)	0.95 (0.93 – 0.97)	0.99 (0.99 – 1.00)
Cross-validated area under the receiver-operator characteristic curve	0.84 (0.80 – 0.87)	0.91 (0.88 – 0.94)	0.94 (0.92 – 0.96)	0.99 (0.98 – 1.00)

^*Akaike information criterion measures model fit, with a lower value indicating a better fit. AGREE, a working group on proton-pump inhibitor responsive esophageal eosinophilia, HPF, high power field.