Table 3.

Predictor variables selected by stepwise selection on the Akaike information criterion for predictor variables limited to information available prior to diagnostic endoscopy, predictor variables limited to information available during diagnostic endoscopy, all predictor variables excluding eosinophil count, and all predictor variables depending on the definition of cases of EoE defined as A Working Group on Proton-pump Inhibitor Responsive Esophageal Eosinophilia (AGREE) consensus definition, as subjects previously diagnosed as PPI-responsive esophageal eosinophilia (PPI-REE), and as previously defined as EoE confirmed with a PPI trial.

AGREE / PPIREE / PPI Trial -, negative predictor +, positive predictor 0, not included	Model limited to clinical criteria that would be available before diagnostic endoscopy	Model limited to clinical and endoscopic criteria that would be available at a diagnostic endoscopy before biopsy	Model with histology in addition to clinical and endoscopic potential predictor variables but excluding eosinophil count	Model with histology in addition to clinical and endoscopic potential predictor variable including eosinophil count
More advanced age	− / − / −	− / − / −	− / − / −	− / 0 / 0
Male sex	+ / + / +	+ / + / 0	+ / + / 0	0 / 0 / 0
White race/ethnicity	+ / 0 / +	0 / 0 / +	0 / 0 / 0	0 / 0 / 0
Atopy or food allergies	+ / 0 / 0	0 / 0 / 0	0 / 0 / −	0 / 0 / 0
Dysphagia	+ / + / +	+ / + / +	+ / + / 0	+ / 0 / 0
Rings, furrows, white plaques, narrowing, or crepe paper appearance		+ / + / +	+ / + / +	+ / 0 / +
Esophagitis		− / 0 / −	0 / 0 / 0	0 / 0 / 0
Hiatus hernia		− / 0 / −	0 / 0 / −	0 / 0 / −
Eosinophil degranulation			+ / + / +	0 / 0 / 0
Eosinophilic microabscess			+ / 0 / +	0 / − / 0
Spongiosis			0 / 0 / +	0 / 0 / +
Higher peak overall eosinophil count				+ / + / +

EoE, eosinophilic esophagitis, AGREE, A Working Group on Proton-pump Inhibitor Responsive Esophageal Eosinophilia, PPI, proton-pump inhibitor, PPIREE, PPI-responsive esophageal eosinophilia.