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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Transl Res. 2020 Jul 22;228:1–12. doi: 10.1016/j.trsl.2020.07.009

Figure 2.

Figure 2.

12-miRNA and 21-gene signatures of IPF. (A) Heatmap of 12-miRNA signature. Red represents increased miRNA expression while blue represents decreased expression. Subjects are labeled by their corresponding DLCO and FVC % predicted (DLCO ∣ FVC). (B) Kaplan-Meier curves for patients from study cohort with high and low risk scores. High scores correspond to the higher predicted risk and low scores correspond to the lower predicted risk. The P-values for both the 12-miRNA and 21-gene signatures are measured by log-rank test. (C) Enriched pathways among the prioritized 712 genes in IPF. The top 20 ranked KEGG pathways are listed. The red line indicates the cutoff of significance (0.05). The number of genes in each pathway is shown beside the pathway name. (D) Heatmap of 21-gene signature. Red represents increased gene expression while blue represents gene expression. The patients are labeled by their corresponding DLCO and FVC % predicted (DLCO ∣ FVC).