Table 3.

The 21-gene signature in IPF PBMCs

			DLCO		FVC
Gene	miRNAa	SVRb	ρc	$P_{DLCO}^{gene}$	ρc	$P_{FVC}^{gene}$
ABHD10	hsa-miR-223	−1.2577	0.49	5.30×10−4	0.46	9.89×10−4
ATP2B1	hsa-miR-144	−1.2072	0.51	2.92×10−4	0.41	4.19×10−3
C1orf52	hsa-miR-144	−1.2476	0.46	1.24×10−3	0.49	4.49×10−4
DECR1	hsa-miR-223	−1.2593	0.41	3.78×10−3	0.46	1.06×10−3
DNAJC2	hsa-miR-144	−1.3116	0.53	1.07×10−4	0.48	5.79×10−4
DST	hsa-miR-144	−1.3074	0.47	9.01×10−4	0.57	2.40×10−5
DUSP10	hsa-miR-223	−1.2357	0.39	6.79×10−3	0.42	2.95×10−3
EXOSC9	hsa-miR-144	−1.2346	0.55	6.83×10−5	0.38	7.40×10−3
FBXW7	hsa-miR-223	−1.3105	0.69	7.22×10−8	0.40	4.82×10−3
HTRA1	hsa-miR-31	−1.2449	−0.60	7.89×10−6	−0.42	2.61×10−3
INPP5B	hsa-miR-223	−1.2291	0.40	5.70×10−3	0.56	4.21×10−5
LCP2	hsa-miR-144	−1.2774	0.56	4.12×10−5	0.38	8.30×10−3
MSI1	hsa-miR-548e	−1.3278	−0.56	5.11×10−5	−0.44	2.00×10−3
PRKRA	hsa-miR-144	−1.2368	0.48	7.11×10−4	0.42	3.06×10−3
RBMXL2	hsa-miR-150	−1.2373	−0.56	4.50×10−5	−0.42	2.96×10−3
REL	hsa-miR-144	−1.2180	0.53	1.45×10−4	0.42	2.90×10−3
SLC35F5	hsa-miR-144	−1.2466	0.44	1.90×10−3	0.38	8.02×10−3
SUCLG2	hsa-miR-144	−1.2016	0.53	1.17×10−4	0.37	9.09×10−3
TTC35	hsa-miR-223	−1.3046	0.44	2.16×10−3	0.41	3.99×10−3
	hsa-miR-144	−1.3256
USP16	hsa-miR-223	−1.2207	0.45	1.32×10−3	0.42	2.96×10−3
YTHDF2	hsa-miR-144	−1.3317	0.51	2.60×10−4	0.46	9.80×10−4

^aSilencing miRNAs for the protein-coding genes in 21-gene signature

^bAbbreviation of mirSVR score, ranking miRNA-mRNA binding

^cSpearman’s rank correlation coefficient between gene expression level and DLCO/FVC