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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Gynecol Oncol. 2020 Nov 1;160(1):71–76. doi: 10.1016/j.ygyno.2020.10.019

Table 2.

Dose level and schedules with occurrence of dose-limiting toxicity of each regimen.

Regimens Days per Cycle Carboplatin/Paclitaxel Dosing Selinexor Dosing (Level 1) No. of Patients Dose-Limiting Toxicity
1 21 Carboplatin AUC 5 IV, Day 1 Paclitaxel 175 mg/m2 IV, Day 1 Selinexor 30 mg/m2 orally, Day 1,4, 8, 11, 15, and 18 3 0
2 21 Carboplatin AUC 5 IV, Day 1 Paclitaxel 80 mg/m2 IV, Day 1,8,15 Selinexor 30 mg/m2 orally, Day 1,4, 8, 11, 15, and 18 7 1 Grade 3 syncope
3 21 Carboplatin AUC 5 IV, Day 1 Paclitaxel 80 mg/m2 IV, Day 1,8,15 Selinexor 60 mg, orally, Day 1, 8, 15 6 0
4 21 Carboplatin AUC 5 IV, Day 1 Paclitaxel 175 mg/m2 IV, Day 1 Selinexor 60 mg, orally, Day 1, 8, 15 7 0

AUC=area under the curve, DLT=dose-limiting toxicity