Table 3.
Treatment-related adverse events of grades 1–4 occurring in >20% of all patients (N=23)
| Regimen 1 | Regimen 2 | Regimen 3 | Regimen 4 | All Patients | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Adverse Event | (N=3) | (N=7) | (N=6) | (N=7) | (N=23) | |||||
| Thrombocytopenia | 3 | 2 | 7 | 2 | 6 | 1 | 7 | 2 | 23 (100 %) | 7 (30%) |
| Leukopenia | 3 | 3 | 7 | 3 | 6 | 5 | 7 | 5 | 23 (100 %) | 16 (70%) |
| Neutropenia | 2 | 2 | 6 | 5 | 6 | 4 | 7 | 5 | 21 (91%) | 16 (70%) |
| Hyperglycemia | 3 | 0 | 7 | 2 | 6 | 2 | 4 | 0 | 20 (87%) | 4 (17%) |
| Hypomagnese mia | 2 | 0 | 5 | 1 | 6 | 4 | 6 | 0 | 19 (83%) | 5 (22%) |
| Anemia | 3 | 2 | 6 | 4 | 6 | 5 | 3 | 2 | 18 (78%) | 13 (57%) |
| Hypoalbumine mia | 2 | 0 | 5 | 0 | 5 | 0 | 6 | 1 | 18 (78%) | 1 (4%) |
| ALT increase | 2 | 0 | 5 | 3 | 6 | 5 | 5 | 2 | 18 (78%) | 10 (43%) |
| Nausea | 3 | 1 | 5 | 1 | 4 | 0 | 3 | 1 | 15 (65%) | 3 (13%) |
| Lymphopenia | 3 | 3 | 3 | 3 | 4 | 3 | 5 | 5 | 15 (65%) | 14 (61%) |
| Hyponatremia | 3 | 1 | 7 | 0 | 3 | 1 | 2 | 0 | 15 (65%) | 2 (9%) |
| Fatigue | 3 | 0 | 5 | 1 | 3 | 0 | 3 | 0 | 14 (61%) | 1 (4%) |
| Hypocalcemia | 2 | 1 | 4 | 0 | 3 | 0 | 4 | 2 | 13 (57%) | 3 (13%) |
| AST increase | 2 | 0 | 4 | 0 | 3 | 1 | 2 | 1 | 11 (48%) | 2 (9%) |
| Anorexia | 2 | 0 | 6 | 0 | 2 | 0 | 1 | 0 | 11 (48%) | 0 |
| Constipation | 2 | 0 | 3 | 0 | 2 | 0 | 4 | 0 | 11 (48%) | 0 |
| Alopecia | 0 | 0 | 5 | 0 | 2 | 0 | 3 | 0 | 10 (43%) | 0 |
| Prolonged APTT | 1 | 0 | 3 | 1 | 2 | 0 | 4 | 0 | 10 (43%) | 1 (4%) |
| Increased INR | 1 | 0 | 2 | 1 | 3 | 0 | 3 | 1 | 9 (39%) | 2 (9%) |
| Vomiting | 2 | 0 | 1 | 0 | 3 | 1 | 3 | 1 | 9 (39%) | 2 (9%) |
| Hypokalemia | 1 | 1 | 2 | 1 | 1 | 0 | 4 | 4 | 8 (35%) | 6 (26%) |
| ALP increase | 0 | 0 | 2 | 0 | 2 | 0 | 4 | 0 | 8 | 0 (35%) |
| Neuropathy | 1 | 0 | 1 | 0 | 3 | 1 | 2 | 0 | 7 (30%) | 1 (4%) |
| Weight loss | 1 | 0 | 2 | 0 | 3 | 1 | 1 | 0 | 7 (30%) | 1 (4%) |
| Diarrhea | 1 | 0 | 3 | 0 | 1 | 0 | 1 | 0 | 6 (26%) | 0 |
ALP=alkaline phosphatase, ALT=alanine transaminase, APTT= activated partial thromboplastin time; AST=aspartate aminotransferase; INR=international normalized ratio