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. Author manuscript; available in PMC: 2022 Feb 28.
Published in final edited form as: Cancer Lett. 2020 Nov 27;499:188–200. doi: 10.1016/j.canlet.2020.11.031

Figure 3. UTX activates chemokine gene expression through H3K27me3 demethylation.

Figure 3.

A. RT-qPCR analyses of chemokine gene expression in Utx+/+ and UtxF/F Atoh1-Cre SmoM2 medulloblastoma tumors (n=18 for Utx+/+ tumors and n=14 for UtxF/F tumors).

B. UTX deletion in SmoM2 tumors led to increased local H3K27me3 at the promoter regions of the chemokine genes as analyzed by ChIP-qPCR. GAPDH and p16INK4A were used as negative and positive control, respectively (n=3).

Student’s t-test, **, p<0.01.