A. RT-qPCR analyses of chemokine gene expression in
Utx+/+ and UtxF/F
Atoh1-Cre SmoM2 medulloblastoma tumors (n=18 for
Utx+/+ tumors and n=14 for
UtxF/F tumors).
B. UTX deletion in SmoM2 tumors led to increased local H3K27me3 at the
promoter regions of the chemokine genes as analyzed by ChIP-qPCR.
GAPDH and p16INK4A were used as
negative and positive control, respectively (n=3).
Student’s t-test, **, p<0.01.