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. Author manuscript; available in PMC: 2022 Feb 28.
Published in final edited form as: Cancer Lett. 2020 Nov 27;499:188–200. doi: 10.1016/j.canlet.2020.11.031

Figure 8. UTX deletion in medulloblastoma led to impaired neural differentiation.

Figure 8.

A. NeuN, HuC/D, MAP2, and TUBB3 staining of P7 and P14 Utx+/+ and UtxF/F Atoh1-Cre SmoM2 cerebella showed significantly reduced neuron numbers in UTX deleted samples.

B. BrdU tracing (24 hours) experiments revealed decreased differentiation in UtxF/F Atoh1-Cre SmoM2 precancerous CGNPs at P14 than the wildtype CGNPs. The neuron differentiation rate was quantified as the percentage of HuCD+ BrdU+ cells in total BrdU+ cells.

Student’s t-test, **, p<0.01.