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. 2020 Dec 29;6(12):e05826. doi: 10.1016/j.heliyon.2020.e05826

Figure 8.

Figure 8

Combination therapy ameliorated the ER stress-induced PERK-eIF2a pathway and improved insulin signaling. We detected protein expression levels of hepatic ER stress pathway (a) GRP78, (b) p-PERK, and (c) p-eIF2a (d) ATF4. Concomitantly combination of Met and PSTi8 improved insulin sensitivity in liver as identified by improved insulin signaling. We detected protein phosphorylation of (e) p-(Ser-473) AKT (f) p-(Ser-307) IRS-1. Results are presented as means ± SEM (n = 3). Significance among groups presented as β, Control vs HVCD, δ, HVCD vs HVCD + Met; ε, HVCD vs HVCD + PSTi8; φ, HVCD vs HVCD + Comb. Significance represented as φp<0.05; ββ,εε,φφp<0.01;βββ,δδδ,εεε,φφφp<0.001.