Figure 2.
Effects of Ccr2 or Ccr5 deficiency on LPS-induced acute liver injury in NEMO LPC-deficient mice. (A) Hematoxylin and eosin stainings of liver sections from WT, NEMOLPC-KO, NEMOLPC-KOCcr2–/–, and NEMOLPC-KOCcr5–/– mice at the age of 8 weeks that were either left untreated or challenged with LPS for 4 hours at the dose of 0.42 μg/kg. (B) Liver injury (ALT activity) in these animals. (C) Cytokine expression in liver tissue was monitored using a multiplex assay. Data represent median of n = 3–6; ∗P < .05, ∗∗∗P < .001 (1-way analysis of variance).