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. 2020 Sep 4;11(2):327–347. doi: 10.1016/j.jcmgh.2020.08.012

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Role of hepatic macrophage subsets and effects of Ccr5 deficiency on macrophage activation in NEMO LPC-deficient mice. (A) Hepatic macrophage subsets (CD11b⁺F4/80^int monocytic macrophages and CD11b^intF4/80⁺ KCs) were sorted from livers of 8-week-old NEMO^WT and NEMO^LPC-KO mice, and mRNA expression of inflammatory cytokines and markers was quantified using real-time quantitative polymerase chain reaction. (B) BMDMs were generated from 8-week-old NEMO^LPC-KO and NEMO^LPC-KOCcr5^–/– and cultured for 6 days, followed by 24 hours of stimulation with 20-ng/mL IL4, or IFNγ, and mRNA expression of inflammatory markers was analyzed using quantitative real-time polymerase chain reaction. Data represent median of n = 2–6; ∗P < .05, ∗∗∗P < .001 (1-way analysis of variance).