Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 4;11(2):327–347. doi: 10.1016/j.jcmgh.2020.08.012

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Roles of lymphoid immune cell subsets for liver injury in NEMO parenchymal cell–deficient mice. Specific lymphoid immune cell subsets were depleted in vivo using monoclonal antibodies in NEMO^WT, NEMO^LPC-KO, NEMO^LPC-KOCcr2^–/–, and NEMO^LPC-KOCcr5^–/– mice at the age of 8 weeks. (A) Treatment with 100 μg of anti-CD8 antibody (clone TIB 210) reduces CD8⁺ T cells (representative fluorescence-activated cell sorting plots from peripheral blood and liver, 24 hours after monoclonal antibody injection), but does not affect liver injury (depicted as ALT levels, 24 hours after monoclonal antibody injection). (B) Reduction of NK and NK T cells by 100-μg anti-NK1.1 antibody (clone PK136) in blood and liver after 24 hours. (C) Effects of 1 mg/kg body weight dexamethasone (DEX) on liver injury. Data represent median of n = 4–6 ± SD; ∗P < .05, ∗∗∗P < .001 (1-way analysis of variance). FSC, forward scatter.