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. 2020 Dec 21;11:584374. doi: 10.3389/fneur.2020.584374

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Copyright © 2020 Lang, Gan, Yoon, Hanganu, Kibreab, Cheetham, Hammer, Kathol, Sarna, Martino and Monchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Study protocol. (B) Functional connectivity analysis outline. (i) Region of interest (ROI) to ROI analysis. An ROI–ROI analysis was performed, specifically assessing the connectivity between the stimulation site and the left caudate head, along with five other striatal subregions. (ii) Left striatal subregions were obtained from a functional parcellation of the striatum (28). (iii) Connectivity within and between the striatal network and stimulation network was assessed. Striatal network consisted of the six subregions of the left striatum. Stimulation network consisted of seven cortical ROIs, which display strong functional connectivity with the stimulation site. (iv) An ROI–whole brain analysis was performed with the stimulation site and each of the six left striatal subregions.