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. 2020 Dec 21;11:601090. doi: 10.3389/fphys.2020.601090

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Copyright © 2020 Sztretye, Singlár, Balogh, Kis, Szentesi, Angyal, Balatoni, Csernoch and Dienes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activity-dependent changes in mitochondrial calcium uptake in single FDB fibers from Cmpt mice. (A) Representative image of rhod-2 AM fluorescence in a live Cmpt FDB fiber at rest. (B) Average (± SEM) change of normalized mitochondrial fluorescence (F_mito) calculated as (F_I–band – F_A–band)/F_A–band in WT and Cmpt FDB fibers at rest, following 1, and 5 consecutive tetani (n = 8 cells, N = 3 mice). Note the tendency of mitochondrial calcium accumulation and the higher starting values of the normalized F_mito observed in Cmpt. (C) Mitochondrial fluorescence measured along the line arbitrarily drawn in parallel with the longitudinal axis of the WT (black) and Cmpt (red) fiber at rest (a), following the first (b), and the fifth consecutive tetanus (c). * denotes significant difference between WT and Cmpt at p < 0.05.