Figure 2. CCR5^−/− mice are susceptible to systemic candidiasis. WT and Ccr5^−/− mice were intravenously injected with 3×10⁵ CFUs of C. albicans. (A) Survival curves (n=12 mice/group). The log-rank test was used. (B) Changes in body weight (n=4 or 5 mice/group). Unpaired Student t-test was used. (C) Gross morphology of kidneys at day 3 post-infection. (D) Changes in kidney weight (n=8 or 10 kidneys/group). Two-way ANOVA test was used. (E) Fungal burdens at day 3 post-infection were presented per kidney or gram basis (n=6 kidneys/group). The Mann-Whitney U test was used. (F) Histopathologic findings: H&E staining (upper panels); PAS staining (lower panels). Results are representative of 2–4 experiments and are presented as the mean±SEM.

^**p<0.01; ^***p<0.001.