Table 4. Performance of iodine-related parameters in diagnosing small cell lung cancer and non-small cell lung cancer.
| AUC (95% CI) | Cutoff | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | |
|---|---|---|---|---|---|---|---|
| CT 40 keV | |||||||
| AP | 0.81 (0.71–0.88) | 138.40 | 90.48 | 66.67 | 85.07 | 76.92 | 82.80 |
| λHU | |||||||
| AP | 0.84 (0.75–0.91) | 1.55 | 85.71 | 70.00 | 85.71 | 70.00 | 80.65 |
| VP | 0.78 (0.69–0.86) | 1.97 | 96.83 | 56.67 | 82.43 | 89.47 | 83.87 |
| NIC | |||||||
| AP | 0.89 (0.81–0.95) | 0.14 | 93.65 | 70.00 | 86.76 | 84.00 | 86.02 |
| VP | 0.81 (0.72–0.89) | 0.37 | 65.08 | 86.67 | 91.11 | 54.71 | 72.04 |
| NAEF | 0.77 (0.67–0.85) | 0.43 | 57.14 | 90.00 | 92.31 | 50.00 | 67.74 |
The results were obtained by taking NSCLC as a positive diagnosis. Data of AUC are presented as 95% confidence intervals. SCLC, small cell lung cancer; NSCLC, non-small cell lung cancer; AUC, area under the ROC curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; AP, arterial phase; VP, venous phase; CT40keV, the value of 40 keV monochromatic images; λHU, the slope of the spectral HU curve; NIC, the normalized iodine concentration; NAEF, the normalized arterial enhancement fraction; HU, Hounsfield unit.