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. 2020 Nov 17;112(1):144–154. doi: 10.1111/cas.14712

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© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Eomes‐CCL20‐CCR6 pathway regulates migration of Tregs. A, The effect of Eomes knockdown cell line supernatant on Tregs chemotaxis in patients with ESCC by flow cytometry. B, Statistical analysis of (A). C, TCGA database analysis of the correlation between Eomes and Foxp3 expression in ESCC patients’ tissues. D, The effect of Eomes knockdown cell line supernatant on the chemotactic capacity for Tregs. E, Effect of Eomes knockdown cell line supernatant on chemotaxis of PBMC. F, Transwell assay detects the chemotactic ability of Tregs after adding CCL20 recombinant protein in vitro. G, Effect of Eomes on Tregs chemotaxis was detected after neutralizing CCL20. H, TCGA database analysis of the correlation between CCL20 and CCR6 expression in ESCC tissues. I, CCL20‐CCR6 pathway affects the chemotaxis of Tregs as shown using CCL20 recombinant protein and CCR6 neutralizing antibody. Data are presented as mean ± SD. **P < .01, ***P < .001