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. 2020 Dec 3;112(1):101–116. doi: 10.1111/cas.14643

FIGURE 8.

FIGURE 8

Schematic representation of the main processes of URB1 targeting the X‐box binding protein 1 (XBP1)‐activating transcription factor 4 (ATF4) regulatory axis involved in colorectal cancer (CRC) proliferation. Upregulation of URB1 activates the transcription factor XBP1, which further stimulates ATF4 mRNA transcription and ultimately promotes CRC cell proliferation. Cyclin A2 (CCNA2) could be a potential executor of the URB1‐XBP1‐ATF4 axis in CRC