Figure 1.

Clonal hematopoiesis (CH) variants and circulating tumor DNA (ctDNA) detection rates. A, Number of variants detected from cfTNA and white blood cell (WBC) sequencing. B, Genomic landscape of cell‐free total nucleic acid (cfTNA)‐WBC‐matched variants. C, Overall ctDNA detection rate with and without excluding CH‐associated variants. D, ctDNA detection rates across breast cancer disease stages with and without excluding CH‐associated variants. Number of patients shown below each corresponding bar. E, Comparison of WBC‐matched with tumor‐derived variants variant allele frequency (VAF) solely from cfTNA sequencing. Tumor‐derived variants (n = 57), WBC‐matched variants (n = 17). Number of variants shown below each corresponding bar