TABLE 3.
Treatment‐related adverse events occurring in ≥ 5% of patients
| Events | All Grades | Grade 3‐4 |
|---|---|---|
| Patients with ≥ 1 treatment‐related adverse event, n (%) | 106 (94) | 43 (38) |
| Anemia | 31 (27) | 8 (7) |
| Pyrexia | 22 (19) | 0 |
| Decreased appetite | 21 (19) | 4 (4) |
| Increased aspartate aminotransferase | 19 (17) | 2 (2) |
| Increased alanine aminotransferase | 18 (16) | 4 (4) |
| Increased blood creatinine | 17 (15) | 2 (2) |
| Constipation | 17 (15) | 0 |
| Hyponatremia | 17 (15) | 6 (5) |
| Pruritus | 17 (15) | 0 |
| Urinary tract infection | 16 (14) | 4 (4) |
| Rash | 15 (13) | 0 |
| Hypoalbuminemia | 14 (12) | 0 |
| Hypothyroidism | 11 (10) | 0 |
| Upper respiratory tract infection | 10 (9) | 3 (3) |
| Nausea | 9 (8) | 0 |
| Vomiting | 9 (8) | 0 |
| Increased blood bilirubin | 8 (7) | 3 (3) |
| Increased blood urea | 8 (7) | 0 |
| Abdominal distension | 7 (6) | 0 |
| Asthenia | 7 (6) | 1 (1) |
| Diarrhea | 7 (6) | 2 (2) |
| Increased blood alkaline phosphatase | 7 (6) | 1 (1) |
| Increased gamma‐glutamyl transferase | 7 (6) | 3 (3) |
| Proteinuria | 7 (6) | 0 |
| Abdominal pain | 6 (5) | 2 (2) |
| Decreased neutrophil count | 6 (5) | 0 |
| Decreased white blood cell count | 6 (5) | 0 |
| Edema peripheral | 6 (5) | 1 (1) |
| Fatigue | 6 (5) | 1 (1) |
| Hematuria | 6 (5) | 2 (2) |
| Hyperglycemia | 6 (5) | 1 (1) |
| Hyperthyroidism | 6 (5) | 0 |
| Increased blood lactate dehydrogenase | 6 (5) | 0 |