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. 2020 Nov 27;11(1):322–332. doi: 10.1002/2211-5463.13026

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© 2020 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — Effect of miR‐22 mimics/inhibitor on lipid accumulation in human hepatocytes. (A)/(B) Effect of miR‐22 mimics/inhibitor on Sirt1 protein levels in hepatocytes. (C) Effect of miR‐22 mimics/inhibitor on Sirt1 mRNA levels in hepatocytes. (D) Effect of miR‐22 mimics/inhibitor on TG levels in hepatocytes. (E) Effect of miR‐22 mimics/inhibitor on the lipid content of hepatocytes examined via oil red O staining and microscopy. Scale bars: 50 µm. (F) Effect of miR‐22 mimics/inhibitor on relative cell viability of hepatocytes. Data were presented as mean ± SD for three independent experiments. Student's t‐test was conducted. ^* P < 0.05.