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. 2020 Dec 17;9(12):e1229. doi: 10.1002/cti2.1229

Figure 3.

Figure 3

Dopamine‐2 receptor (D2R)‐specific T‐cell‐positive patients exhibited a pro‐inflammatory cytokine profile. Peripheral blood mononuclear cells of D2R‐specific T‐cell‐positive patients (n = 6) were stimulated with immunodominant sub‐pools 4, 5 and 10. The supernatant of each sub‐pool stimulation was tested once in duplicates on a multiplex cytometric bead array and IFN‐γ ELISA to characterise the cytokine secretions. Compared to the controls (dashed line = normalised median of controls), D2R‐specific T‐cell‐positive patients had (a) elevated levels of pro‐inflammatory cytokines IL‐2 (4/6), IFN‐γ (1/3), TNF (4/6), IL‐6 (5/6), IL‐17A (4/6) and IL‐17F (3/6), and slightly higher IL‐21 (1/6). (b) Contrastingly, D2R‐specific T‐cell‐positive patients had similar concentration of Th2 cytokines (6/6) as the controls.