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Arbutin attenuates MTHFD1L and CCND1 expression and might inactivate the AKT/mTOR pathway. The expressions of MTHFD1L, CCND1, AKT/p‐AKT and mTOR/p‐mTOR were investigated by using western blot in Arbutin‐treated OS cells. The intensity of protein bands was quantified. Data are shown as the means ± SD of three independent experiments. The data were statistically analyzed by Student’s t‐test. **P < 0.01 versus NC group.
