Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 16;11(1):300–311. doi: 10.1002/2211-5463.13027

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig 3 — The effect of down‐regulation of miR‐34a‐5p/SIRT1 on the IL‐1β/COX2/PGE2 inflammation pathway and CGRP release in trigeminal ganglion. (A) The expression and localization of miR‐34a‐5p in each group was detected by FISH assay (scale bar: 50 μm). (B) The release of PGE2 in each group was examined by ELISA. (C) The release of IL‐1β in each group was detected by ELISA. (D) The release of CGRP in each group was detected by ELISA. (E) The expressions of SIRT1, COX2, IL‐1β, p65 and AC‐p65 in each group were detected by Western blot. Data are shown as means ± SD. *P < 0.05, versus the control group; ^# P < 0.05, versus the miRNA inhibitor control + SIRT1 siRNA group; ^& P < 0.05, versus the miRNA34a‐5p inhibitor + siRNA control group. Each experiment was repeated three times with similar results.