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. 2020 Dec 16;11(1):300–311. doi: 10.1002/2211-5463.13027

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© 2020 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig 5 — The effect of up‐regulation of miR‐34a‐5p/IL‐1β on the SIRT1/COX2/PGE2 inflammation pathway and CGRP release in trigeminal ganglion. (A) The expression and localization of miR‐34a‐5p in each group was detected by FISH assay (scale bar: 50 μm). (B) The release of PGE2 in each group was examined by ELISA. (C) The release of IL‐1β in each group was detected by ELISA. (D) The release of CGRP in each group was detected by ELISA. (E) The expressions of SIRT1, IL‐1β, p65, AC‐p65 and COX2 in each group were detected by western blot. Data are shown as means ± SD. *P < 0.05, versus the control group; ^# P < 0.05, versus the miRNA control + IL‐1β siRNA group; ^& P < 0.05, versus the miRNA34a‐5p + siRNA control group. Each experiment was repeated three times with similar results.