Table 3.
1-year Loco-regional failure prediction performance of radiomic signature and volumetric predictors.
| Experimental cohort |
Validation cohort |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | PPR | NPR | Accuracy | Sensitivity | Specificity | PPR | NPR | Accuracy | |
| RS_cutoff | 75.60% | 82.90% | 81.60% | 77.30% | 79.27% | 83.33% | 77.30% | 66.70% | 89.50% | 79.41% |
| V35 | 53.70% | 80.50% | 73.33% | 63.50% | 67.07% | 58.30% | 81.80% | 63.60% | 78.30% | 73.53% |
| V30 | 58.50% | 70.70% | 66.70% | 63.00% | 64.63% | 66.70% | 81.80% | 66.70% | 81.80% | 76.47% |
| V25 | 73.20% | 56.10% | 62.50% | 67.60% | 64.63% | 75.00% | 77.30% | 64.30% | 85.00% | 76.47% |
| Stage III/IVA | cT4a | |||||||||
| Sensitivity | Specificity | PPR | NPR | Accuracy | Sensitivity | Specificity | PPR | NPR | Accuracy | |
| RS_cutoff | 70.00% | 82.60% | 77.80% | 76.00% | 76.74% | 75.90% | 65.20% | 73.30% | 68.20% | 71.15% |
| V35 | 45.00% | 82.60% | 69.20% | 63.30% | 65.12% | 58.60% | 65.00% | 68.00% | 55.60% | 61.54% |
| V30 | 50.00% | 73.90% | 63.00% | 62.50% | 62.79% | 62.10% | 47.80% | 60.00% | 50.00% | 55.77% |
| V25 | 65.00% | 60.00% | 59.10% | 66.70% | 62.79% | 75.90% | 26.10% | 56.40% | 46.20% | 51.92% |
Abbreviations: RS, radiomic signature; RS_cutoff, RS of 0.0326 cutoff point; V35/V30/25, tumor volume of 35/30/25 cm3 cutoff point; PPR, positive predictive ratio; NPR, negative predictive ratio.