Figure EV4. Binding of OSKM to the O/S/K/M genes in MEFs and to nine TR genes in human fibroblasts.

1. Shown are ChIP‐seq big wig files in IGV browser depicting binding of Oct4 (red), Sox2 (blue), Klf4 (green), and c‐Myc (black) to regulatory regions of the O/S/K/M/ genes in MEFs undergoing reprogramming at the 18 h, day 3, and day 5, as well as in control MEFs, mESCs, and miPSCs. The relative sizes of the represented genomic loci and the corresponding TSSs are also indicated. The side color bar depicts the expression levels of each TR at the indicated time points. All peaks have been normalized against input DNA
2. Shown are ChIP‐seq big wig files in IGV browser depicting OSKM binding to regulatory regions of the indicated TRs on day 2 of human fibroblasts undergoing reprogramming. The results shown were derived from meta‐analyses of the published ChIP‐seq data from K.S Zaret Lab (Soufi et al, 2012).