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. Author manuscript; available in PMC: 2021 Jan 4.
Published in final edited form as: Sci Transl Med. 2016 Aug 17;8(352):352ra110. doi: 10.1126/scitranslmed.aaf6843

Fig. 3. In vivo local CD25-targeted NIR-PIT induces rapid activation and cytotoxicity of intratumoral CD8 T and NK cells.

Fig. 3.

(A) Cytotoxic action of CD8 T and NK cells infiltrating LL/2-luc or MC38-luc tumors was examined by flow cytometry with or without local CD25-targeted NIR-PIT. CD8 T and NK cells collected 1.5 hours after PIT were producing IFN-γ and IL-2 and had CD107a exposed on the cell surface, whereas the cells from nontreated tumors did not (n = 5; *P < 0.008, Mann-Whitney test). (B) One day after local CD25-targeted NIR-PIT, up-regulation of activation markers, CD69 and CD25, and continued production of IL-2 in both CD8 T and NK cells were observed (n = 5; *P < 0.008, Mann-Whitney test).