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. Author manuscript; available in PMC: 2021 Jan 4.
Published in final edited form as: Sci Transl Med. 2016 Aug 17;8(352):352ra110. doi: 10.1126/scitranslmed.aaf6843

Fig. 5. Activated CD8 T and NK cells are present in the contralateral tumor after ipsilateral CD25-targeted NIR-PIT.

Fig. 5.

(A to D) CD8 T and NK cells collected from nonirradiated left dorsal tumors in mice receiving local CD25-targeted NIR-PIT of the right dorsal tumors were analyzed for their expression of activation markers 1 day after the treatment. CD8 T and NK cells producing IFN-γ (A) and IL-2 (B) and with up-regulated CD25 (C) and CD69 (D) expression were present in the nonirradiated left tumor after CD25-targeted NIR-PIT of the right-side tumor [n = 5; *P = 0.0021 (A: CD8 T cells), P = 0.0023 (B: CD8 T cells), P = 0.0012 (D: CD8 T cells), P < 0.008 (others), Mann-Whitney test].