Table 2.

Histologic and immunohistochemical features of the five intracranial DSRCTs within our series.

Case #	Initial diagnostic impression	Desmoplastic stroma	Mitotic index	Ki‐67 LI	Necrosis	Myogenic markers	Epithelial markers	Neuronal markers
1	Glial neoplasm with an astroblastoma‐like pattern	Markedly desmoplastic stroma	Less than 1/10 HPFs	2%	Not present	Desmin: patchy strong positivity	EMA: focal, CAM 5.2: negative Cytokeratin, MCK: negative	Synaptophysin: focal, NeuN: patchy, Neurofilament: negative, CD56: positive
2	Malignant tumor, not otherwise specified (NOS)	Only focal desmoplasia	10/10 HPFs	–	Foci of necrosis	Desmin: diffusely positive	EMA: negative, CAM 5.2: negative, AE1/AE3: negative	Synaptophysin: negative
3	Favor anaplastic medulloblastoma, WHO grade IV	Not present	12/10 HPFs	80%	Foci of necrosis	Desmin: diffusely positive, SMA: negative	EMA: extensively positive, CAM 5.2: patchy, CK7: focal, CK20: focal	Synaptophysin: patchy, NeuN: patchy, Neurofilament: patchy
4	Low‐grade glioneuronal tumor	Markedly desmoplastic stroma	Less than 1/10 HPFs	8%	Not present	Desmin: diffusely positive, Myogenin: negative	EMA: focal, CAM 5.2: negative, Pan‐cytokeratin: focal	Synaptophysin: focal, NeuN: patchy, Neurofilament: negative, CD56: positive
5	Small round blue cell tumor	Only focal desmoplasia	–	–	–	Desmin: strongly positive, Myogenin: negative, SMA: focally positive	EMA: negative, CAM 5.2: negative, Pan‐cytokeratin: negative	Synaptophysin: focal, CD56: positive