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. 2021 Jan 4;40:5. doi: 10.1186/s13046-020-01794-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — CHKA silencing increased TRAIL-R2 membrane expression and triggering/function. a. Expression of total TRAIL-R2 protein assessed by both flow cytometry after cells permeabilization (left panel) and Western blotting (right panel) in siCHKA and siNT cell lines. b. Membrane surface expression of TRAIL-R2 detected by flow cytometry after CHKA silencing and recovery of ChoKα expression. In both A and B, representative experiments are shown. Fluorescence index are reported. C. Percentage of growth inhibition obtained following 16 h treatment with specific anti-TRAIL-R2 agonist antibody; asterisks are referred to statistically significant differences