Table 1.
Association between patient characteristics and co-dispensing of oral anticoagulants (OACs) with ≥1 episodes of enzyme-inducing antiepileptic drugs (EI-AEDs) versus only non-enzyme-inducing antiepileptic drugs (NEI-AEDs), 2018
| Adults with Epilepsy on OACs | |||
|---|---|---|---|
| ≥1 Episodes of EI-AEDs with OACs (n= 4,837) | Only NEI-AEDs with OACs (n= 7,584) | Adjusted OR of ≥1 Episodes of EI-AEDs with OACs a,b (95% CI) | |
| Age, median (IQR), y | 70 (61-78) | 73 (64-81) | 0.98 (0.98-0.99) |
| Women, No. (%) | 2,569 (53.1%) | 3,808 (50.2%) | 1.13 (1.05-1.22) |
| Race, No. (%) | |||
| White | 2,992 (61.9%) | 4,358 (57.5%) | Reference |
| Black | 646 (13.4%) | 1,087 (14.3%) | 0.75 (0.66-0.84) |
| Hispanic | 291 (6.0%) | 497 (6.6%) | 0.79 (0.68-0.93) |
| Asian | 48 (1.0%) | 98 (1.3%) | 0.76 (0.54-1.08) |
| Unknown | 860 (17.8%) | 1,544 (20.4%) | --- |
| Net Worth, No. (%) | |||
| <$25K | 1,199 (24.8%) | 1,594 (21.0%) | Reference |
| $25K-$149K | 660 (13.6%) | 968 (12.8%) | 0.91 (0.81-1.03) |
| $150K-$249K | 350 (7.2%) | 500 (6.6%) | 0.94 (0.81-1.10) |
| $250K-$499K | 467 (9.7%) | 809 (10.7%) | 0.83 (0.72-0.97) |
| >$499K | 540 (11.2%) | 1,117 (14.7%) | 0.78 (0.67-0.91) |
| Unknown | 1,621 (33.5%) | 2,596 (34.2%) | --- |
| Education Level, No. (%) | |||
| High School Diploma or Less | 1,567 (32.4%) | 2,187 (28.8%) | Reference |
| Less than Bachelor Degree | 2,159 (44.6%) | 3,265 (43.1%) | 0.95 (0.87-1.05) |
| Bachelor Degree Plus | 373 (7.7%) | 796 (10.5%) | 0.76 (0.65-0.90) |
| Unknown | 738 (15.3%) | 1,336 (17.6%) | --- |
| Division of the Country, No. (%) | |||
| New England (CT, ME, MA, NH, RI, VT) | 225 (4.7%) | 368 (4.9%) | Reference |
| Middle Atlantic (NJ, NY, PA) | 403 (8.3%) | 737 (9.7%) | 0.89 (0.73-1.10) |
| East North Central (IL, IN, MI, OH, WI) | 706 (14.6%) | 1,005 (13.3%) | 1.08 (0.89-1.31) |
| West North Central (IA, KS, MN, MO, NE, ND, SD) | 395 (8.2%) | 534 (7.0%) | 1.09 (0.88-1.35) |
| South Atlantic (DE, DC, FL, GA, MD, NC, SC, VA, WV) | 1,315 (27.2%) | 2,140 (28.2%) | 0.95 (0.79-1.14) |
| East South Central (AL, KY, MS, TN) | 243 (5.0%) | 341 (4.5%) | 1.05 (0.83-1.33) |
| West South Central (AR, LA, OK, TX) | 630 (13.0%) | 833 (11.0%) | 1.12 (0.91-1.36) |
| Mountain (AZ, CO, ID, MT, NV, NM, UT, WY) | 460 (9.5%) | 748 (9.9%) | 0.97 (0.79-1.19) |
| Pacific (AK, CA, HI, OR, WA) | 450 (9.3%) | 863 (11.4%) | 0.91 (0.74-1.11) |
| Unknown | 10 (0.2%) | 15 (0.2%) | --- |
a
Adjusted for age, gender, race, net worth, education level, and division.
b
Missingness was imputed for gender, race, net worth, and education level using all assessed variables.
Abbreviations: EI-AED=enzyme-inducing antiepileptic drug; NEI-AED=non-enzyme-inducing antiepileptic drug; OAC=oral anticoagulant