(A, C, E) This 53-year-old woman (Case 1) underwent intramuscular Profound RF treatment of the frontalis (54 insertions) and orbicularis oris (upper lip, 53 insertions; lower lip, 29 insertions). (B, D, F) Nine months after the procedure, the patient’s forehead rhytids were reduced and the medial brow was elevated, lifting the skin excess of the medial upper eyelid. The position of the oral commissure was lifted, and there was increased vermilion show, especially of the lateral upper lip. Although the patient initially appears to be smiling in the postoperative photographs, all views portray a consistent position of the oral commissure (ie, non–muscle-activated smiling). That is, the perceived change in facial expression is due to the tightening effect of the RF microneedling treatment.