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. 2021 Jan 4;14:3. doi: 10.1186/s40545-020-00282-8

Fig. 2.

Fig. 2

Estimated regression coefficients. The imminence of generic entry negatively impacts the chances of a new indication being developed for an NME. Holding the effect of age constant, generic entry’s influence upon reducing the chances of a new indication addition is strongest when generic has already occurred and weakest when generic entry is still 5–10 years into the future