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. 2021 Jan 4;22:5. doi: 10.1186/s13059-020-02232-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Stepwise chromosome compaction by iterative SGC. a Stepwise chromosome compaction by three rounds of iterative SGC. The LU profiles of selected 5-FOA resistant strains after SGC are shown using the strategy as detailed in Fig. 2a. The newly deleted LUs in each round of SGC are indicated by asterisks. b The number of LUs deleted in strains in a. ZLY298 is identified after the first round of SCRaMbLE. ZLY348 is from the second round of SGC and ZLY349 is from the third round of SGC. c The lengths of deleted synthetic sequence in strains in a. d The numbers of deleted genes in strains in a