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. 2021 Jan 4;28:4. doi: 10.1186/s12929-020-00697-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — SOCS2 overexpression inhibits BC cell proliferation, migration, invasion and EMT. a SOCS2-overexpressing plasmid (SOCS2) was transfected into BT-549 and MDA-MB-231 cells, followed by western blot analysis of SOCS2 protein level. b CCK-8 assays were used to determine the effect of SOCS2 on cell viability. c Colony forming assays were performed in BT-549 and MDA-MB-231 cells with SOCS2 overexpression. d, e Transwell assays were applied to evaluate the migration and invasion abilities of SOCS2-overexpressing cells. f Western blot analysis of E-cadherin, N-cadherin and vimentin expressions in SOCS2-transfected cells. **P < 0.01, ***P < 0.001