Fig. 1.

Genetic landscape of somatic mutations identified by whole-exome sequencing of 30 upper tract urothelial carcinomas (UTUC), including 15 muscle-invasive tumors and 15 non-muscle-invasive tumors. a Distribution of somatic mutations showing that non-synonymous mutations are the most frequent type. b OncoPrint depicting mutational load and most frequently mutated genes identified (≥ 10% of cases) in the whole UTUC cohort. c Heatmap for genes with mutual exclusivity or co-occurrence in the whole UTUC cohort. Stars refer to correlations that are statistically significant