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. 2021 Jan 4;22:7. doi: 10.1186/s13059-020-02230-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Distribution of mutations affecting ZFP36 family genes in UTUC and several public bladder carcinoma datasets. Lollipops represent mutations of a ZFP36L1, b ZFP36L2, and c ZFP36 genes. d Distribution of mutation frequency of ZFP36L1 in different public bladder carcinoma cohorts using the cBioPortal database. e Distribution of mutation frequency of ZFP36 family in different bladder carcinoma cohorts using the cBioPortal database. f Box plot representing the mutational load in UTUC samples according to ZFP36 family gene mutations. g Box plot representing mutational load in bladder carcinoma TCGA cohort according to ZFP36 family mutations. h Kaplan-Meier curves for overall survival of patients with bladder carcinomas in TCGA cohort according to ZFP36 family gene mutations status. i Kaplan-Meier curves for progression-free survival of patients with bladder carcinomas in TCGA cohort according to ZFP36 family mutations