Table 2.
Dysregulated circRNAs in BCa
| Name | CircBase ID | Sponge target | Gene | Function | Types of BCa tissues and BCa cell lines | Ref./PMID |
|---|---|---|---|---|---|---|
| upregulated | ||||||
| circ_0058063 | hsa_circ_0058063 | miR-486-3p | FOXP4 | promoted cell proliferation, invasion, and inhibited apoptosis | 94 cases of BCa and the non-cancerous normal tissues; 5637, BIU-87 and RT-112 cell lines | 32181485 |
| circ_0058063 | hsa_circ_0058063 | miR-145-5p | CDK6 | promoted cell proliferation and migration, inhibited cell apoptosis, and decreased cell cycle arrest | 25 pairs of BCa tissues and adjacent normal tissues; T24 and J82 cell lines | 30362519 |
| circ_0017247 | hsa_circ_0017247 | / | Wnt/β-catenin | promoted cell proliferation and tumor formation, inhibited apoptosis, and decreased cell cycle arrest | 50 BCa tissues and adjacent tissues; UM-UC3, SW780, BIU and J82 cell lines | 32096177 |
| circ_103809 | hsa_circ_0072088 | miR-511 | / | promoted the self-renewal, migration and invasion | 3 pairs of BCa tissues and adjacent normal bladder tissues; T24 and EJ cell lines | 32065779 |
| circ_FNTA | hsa_circ_0084171 | miR-370-3p | FNTA | promoted invasion and decreased chemosensitivity to cisplatin | 41 BCa tissues and adjacent normal bladder tissues; T24, J82, 5637, and UMUC3 cell lines | 32052578 |
| circ_PDSS1 | hsa_circ_0093398 | miR-16 | / | promoted cell proliferation, invasion and migration | 72 BCa and adjacent healthy tissues; HT-1197 and UMUC3 cells | 31868205 |
| circ_403658 | hsa_circ_0004383 | / | LDHA | promoted cell growth and invasion | 123 BCa tissues and the matched adjacent tissues; SW780, 5637, T24, J82 and RT4 cell lines | 31814891 |
| circ_0137439 | hsa_circ_0137439 | miR-142-5p | MTDH | promoted cell proliferation, migration, and metastasis | 116 bladder cancer urine samples and 30 normal samples; T24 and 5637 cell lines | 31777254 |
| circ_VANGL1 | hsa_circ_0002623 | miR-605-3p | VANGL1 | promoted cell proliferation, migration, and invasion | 87 BCa tissues and 37 normal adjacent tissues; T24 and EJ cells | 30146736 |
| circ_VANGL1 | hsa_circ_0002623 | miR-1184 | IGFBP2 | promoted cell proliferation, migration, and invasion | 60 BCa and corresponding paracancerous tissue; J82, T24, EJ, RT-4, UM-UC-3, and TCC cell lines | 31758655 |
| circ_ZFR | hsa_circ_0072088 | miR-377 | ZEB2 | promoted cell growth, migration and invasion, and decreased cell cycle arrest and apoptosis | 104 pairs of BCa tissues and adjacent normal tissues; UMUC3, T24, J82, 5637, SW780, EJ and BIU87 cell lines | 31746333 |
| circ_0001361 | hsa_circ_0001361 | miR-491-5p | MMP9 | promoted cell invasion and metastasis | 69 pairs of BCa tissues and matched adjacent normal bladder epithelial tissues; SV-HUC-1, EJ, UMUC3, RT4, and 5637 cell lines | 31705065 |
| circ_UVRAG | hsa_circ_0023642 | miR-223 | FGFR2 | promoted proliferation, migration, tumor formation, and metastasis | T24, EJ, J82, UM-UC-3, TCC, and RT-4 cell lines | 30387298 |
| circ_0023642 | hsa_circ_0023642 | miR-490-5p | EGFR | promoted cell invasion and metastasis | J82 and UMUC3 cell lines | 31455760 |
| circ_CASC15 | hsa_circ_0075828 | miR-1224-5p | CREB1 | promoteed cell proliferation | 67 pair BCa tissues and matched para-carcinoma tissues; 5637, and T24 cell lines | 31072448 |
| circ_0068871 | hsa_circ_0068871 | miR-181a-5p | FGFR3 | promoted cell proliferation and migration | 32 BCa and adjacent normal tissue; T24, UMUC3, EJ, and J82 cell lines | 30999937 |
| circ_DOCK1 | hsa_circ_0020394 | miR-132-3p | Sox5 | promoted cell proliferation, migration, and tumour growth | 23 BC tissue specimens and 32 normal bladder tissues; BIU-87, EJ-m3, T24 and 5673 cell lines | 30983072 |
| circ_CEP128 | hsa_circ_0102722 | miR-145-5p | SOX11 | promoted cell proliferation, and decreased cell apoptosis and cell cycle arrest | 10 pairs of BCa tissues and adjacent bladder tissues; RT-112, 5637, BIU-87, TCCSUP and HEK293T cell lines | 30134837 |
| circ_CEP128 | hsa_circ_0102722 | miR-145-5p | Myd88 | promoted cell proliferation and migration, and decreased cell apoptosis and cell cycle arrest | 40 BCa specimens and blood samples; 293T, J82 and T24 cell lines | 30939216 |
| circ_0001429 | hsa_circ_0001429 | miR-205-5p | VEGFA | enhanced cell propagation and metastasis, reduced cell apoptosis, and promoted tumor growth and lung metastasis | 20 pairs of BCa tissues and paired adjacent normal bladder tissues; T24 cells and 5637 cells | 30909190 |
| circ_TFRC | has_circ_0001445 | miR-107 | TFRC | promoted the invasion, proliferation and tumor growth, contributed to an EMT phenotype | 57 BCa patients tissues compared with adjacent normal patients tissues, EJ, T24, 5637, UMUC3, BIU87, J82, and SW780 cell lines | 30782157 |
| circ_ELP3 | hsa_circ_0001785 | / | / | promoted cell proliferation, and reduced apoptosis and chemosensitivity to cisplatin | 18 pairs of tissue samples and 30 bladder cancer samples; T24 and 5647 cells | 30745833 |
| circ_PRMT5 | hsa_circ_0031250 | miR-30c | SNAIL1/E-cadherin | promoted cell EMT | 119 UCB tissues with matched adjacent normal bladder tissues; T24, TCC-SUP, 5637, and UM-UC-3 cell lines | 30305293 |
| circ_BPTF | hsa_circ_0000799 | miR-31-5p | RAB27A | promoted cell migration and invasive, and tumor growth | 72 pairs of specimens of BCa tissues and adjacent noncancerous tissues; UM-UC-3 and T24 cell lines | 30103209 |
| circ_0000144 | hsa_circ_0000144 | miR-217 | RUNX2 | promoted cell proliferation and invasion | 21 pairs of BCa tissues and adjacent normal tissues; T24, EJ, UMUC3, RT4 and 253J cell lines | 30098434 |
| circ_PTK2 | hsa_circ_0003221 | / | / | promoted the proliferation and migration | 40 pairs of BCa tissue and blood samples. T24 and 5637 cell lines | 29125888 |
| circ_MYLK | hsa_circ_0002768 | miR-29a | VEGFA/VEGFR2 | accelerated cell proliferation, migration, tube formation, and promoted EMT | 32 pairs bladder carcinomas and matched para-carcinomas; EJ, T24, 5673 and BIU-87 cell lines | 28687357 |
| circ_TCF25 | hsa_circ_0041103 | miR-103a-3p/miR-107 | CDK6 | promoted proliferation and migration | 40 pairs bladder carcinoma tissue and matched para-carcinoma tissues; T24 and EJ cell lines | 27484176 |
| downregulated | ||||||
| circ_FUT8 | hsa_circ_0003028 | miR-570-3p | KLF10 | inhibited migration, invasion, and metastasis | 145 BCa tissues and 50 matched adjacent normal bladder tissues; T24, SV-HUC-1, and UM-UC-3 cell lines | 32072011 |
| circ_RIP2 | hsa_circ_0005777 | miR-1305 | Tgf-β2/smad3 | promoted migration, invasion, clone formation and EMT | 45 paired BCa and the adjacent normal tissues, 58 bladder cancer tissues, 5637 and UM-UC-3 cell lines | 32019579 |
| circ_FAM114A2 | hsa_circ_0001546 | miR-762 | ΔNP63/TP63 | inhibited migration, invasion and proliferation | 31 BCa tissues and paired adjacent noncancer tissues; T24, J82, 5637, and 293T cell lines | 31969560 |
| circ_0091017 | hsa_circ_0091017 | miR-589-5p | / | inhibited cell proliferation, migration and invasiveness | 40 pairs of BCa tissues and normal adjacent tissues; 5637, EJ, T24, UMUC-3, and RT4 cell lines | 31957821 |
| ciRs_6 | hsa_circ_0006260 | miR-653 | March1 | suppressed cell growth and increased cell cycle arrest | 45 paired bladder cancer and the adjacent normal tissues, 58 bladder cancer tissues; 5637 and UM-UC-3 cell lines | 31819015 |
| circ_5912 | hsa_circ_0005912 | / | TGF-β signaling | suppressesed cell proliferation, invasion and migration | 58 BCa tissues and the matched adjacent tissues; T24 and SW780 cell lines | 31808751 |
| circ_PTPRA | hsa_circ_0006117 | miR-636 | KLF9 | inhibited cell proliferation and tumor growth | 104 BCa specimens, 64 matched BC and adjacent normal specimens; T24 and UM-UC-3 cell lines | 31821171 |
| circ_Foxo3 | hsa_circ_0006404 | miR-191-5p | / | promoted cell apoptosis | 30 BCa tissues and adjacent normal bladder tissues; T24, UM-UC-3 and J82 cell lines | 31802888 |
| circ_0071662 | hsa_circ_0071662 | miR-146b-3p | HPGD/NF2 | suppressed cell proliferation and invasion | 97 BCa tissues and matched adjacent normal tissues; BIU-87, T-24, EJ-28 and J82 cell lines | 31757227 |
| circ_PICALM | hsa_circ_0023919 | miR-1265 | STEAP4 | inhibited cell invasion and metastasis | 168 BCa samples and 40 corresponding adjacent normal tissue samples; T24, UM-UC-3, J82, RT-4, and HEK-293T cell lines | 31648990 |
| circ_0137606 | hsa_circ_0137606 | miR-1231 | PHLPP2 | suppressed cell proliferation and metastasis | 13 high-grade BCa, low-grade BCa and a normal controlpatients tissues; T24 and SV-HUC-1 cell lines | 31545480 |
| circ-ZKSCAN1 | hsa_circ_0001727 | miR-1178-3p | p21 | inhibited cell proliferation, migration, invasion and metastasis | 68 BCa tissues and the matched normal tissues; T24, UM-UC-3, 5637, and EJ cell lines | 31481066 |
| circ_NR3C1 | hsa_circ_0001543 | miR-27a-3p | cyclin D1 | inhibited cell proliferation, cell cycle progression, and tumor growth | 42 pairs of BCa tissues and adjacent normal bladder tissues; T24, EJ, UMUC3, J82, and 5637 cell lines | 31255724 |
| circ_SLC8A1 | hsa_circ_0000994 | miR-130b/miR-494 | PTEN | inhibited cell migration, invasion and proliferation | 70 pairs of human bladder cancer tissues compared with their adjacent normal tissues; 5637, T24, J82, EJ, UMUC, and RT4 cell lines | 31228937 |
| circ_Cdr1as | hsa_circ_0001946 | miR-1270 | APAF1 | induced cell apoptosis and enhanced chemosensitivity to cisplatin | 160 BCa tissues; TCCSUP, 5367, T24 and EJ cell lines | 31131537 |
| circ_Cdr1as | hsa_circ_0001946 | miR-135a | / | inhibited cell proliferation, invasion and migration, and tumour growth | 94 pairs of BCa tissues and adjacent normal tissues; EJ and T24 cell lines | 29694981 |
| circ_ACVR2A | hsa_circ_0001073 | miR-626 | EYA4 | suppressed cell proliferation and metastasis | 50BC tissues and matched adjacent normal epithelial tissues; T24, UM-UC-3, RT4, J82, 5637, HT-1376, and TCCSUP cell lines | 31101108 |
| circ_0002024 | hsa_circ_0002024 | miR-197-3p | / | suppressed cell proliferation, migration, and invasion | 20 BCa and normal samples; EJ, 5637, T24, and UMUC-2 cell lines | 30972190 |
| circ_CDYL | hsa_circ_0008285 | / | C-MYC | inhibited cell growth and migration | 30 pairs of BCa tissues and paired surrounding normal bladder tissues; EJ and T24T cells | 30968727 |
| circ_LPAR1 | hsa_circ_0087960 | miR-762 | / | inhibited cell invasion and metastasis | 125 BCa tissues and 68 paired cancer tissues and adjacent non-tumorous tissues; 5637 and T24 cell lines | 30867795 |
| circ_MTO1 | hsa_circ_0007874 | miR-221 | / | inhibited cell EMT and metastasis | 117 bladder cancer tissues and the matched adjacent tissues; UMUC3, SVHUC1, T24, J82 and 5637 cell lines | 30551873 |
| circ_FNDC3B | hsa_circ_0006156 | miR-1178-3p | G3BP2 | inhibited cell proliferation, migration, invasion, tumorigenesis and metastasis | 82 BCa tissues and 56 pairs of BCa tissues and adjacent noncancerous tissues; T24 and UM-UC-3 cell lines | 30458784 |
| circ_UBXN7 | hsa_circ_0001380 | miR-1247-3p | B4GALT3 | inhibited cell proliferation, migration, invasion, and tumor growth | 84 cases of BCa tissues including 30 paired BC tissues and adjacent nontumor tissues; SV-HUC-1, T24 and UM-UC-3 cell lines | 30312173 |
| circ_HIPK3 | hsa_circ_0000284 | miR-558 | HPSE | inhibited cell migration, invasion, and angiogenesis, tumor growth, and metastasis | 44 pairs of bladder cancer tissues and paired adjacent normal bladder tissues; UMUC3, and T24 cell lines | 28794202 |
| circ_BCRC3 | hsa_circ_0001110 | miR-182-5p | p27 | inhibited cell proliferation, and impairs tumor growth, and increased cell cycle arrest | 47 BCa tissues and their adjacent normal bladder tissues; EJ,T24, and SV-HUC-1 cell lines | 30285878 |
| circ_BCRC4 | hsa_circ_0001577 | miR-101 | EZH2 | promoted cell apoptosis and inhibited cell viability | 24 pairs of fresh bladder cancer tissues and surrounding normal adjacent bladder tissues; UMUC3 and T24 cell lines | 29270748 |
| circ_ITCH | hsa_circ_0001141 | miR-17, miR-224 | p21, PTEN | inhibited cell proliferation, migration, invasion and metastasis, induced cell cycle arrest and cell apoptosis | 72 pairs of BCa tumor and normal tissues; UMUC3, T24, J82, 353J, 5637, TCC, EJ and RT4 cell lines | 29386015 |
circRNAs circular RNAs, BCa bladder cancer, EMT epithelial to mesenchymal transition