Table 4.

Univariate and multivariate analyses for OS and PFS

	Univariate analysis				Multivariate analysis
	OS		PFS		OS		PFS
	HR(95%CI)	p-value	HR(95%CI)	p-value	HR(95%CI)	p-value	HR(95%CI)	p-value
Age	1.033 (0.988–1.080)	0.155	1.001 (0.969–1.035)	0.931
Grade 1 vs. grade 2,3	3.566 (0.474–26.854)	0.217	1.862 (0.570–6.080)	0.303
Stage	1.946 (1.096–3.455)	0.023	2.092 (1.385–3.161)	0.000			1.877 (1.154–3.052)	0.011
Serous vs. other histopathology	1.114 (0.452–2.745)	0.814	0.815 (0.417–1.595)	0.550
HE4-median pretreatment	1.893 (0.744–4.815)	0.181	2.325 (1.157–4.673)	0.018			2.315 (1.084–4.941)	0.030
HE4-clearance after 3rd cycle of chemotherapy	8.295 (2.984–23.057)	0.000	3.632 (1.877–7.027)	0.000	8.294 (2.980–23.085)	0.000	2.713 (1.361–5.407)	0.005
CA125-median pretreatment	0.645 (0.259–1.606)	0.346	0.878 (0.456–1.690)	0.697
CA125-clearance after 1st cycle of chemotherapy	2.556 (1.4027–6.361)	0.044	2.435 (1.260–4.709)	0.008	2.549 (1.019–6.378)	0.045	3.853 (1.888–7.865)	0.000