Fig. 6.

MGMT inhibition with CDDP treatment retarded NPC tumor growth. a Tumor volume and b body weight in mice bearing tumors were measured twice weekly. Tumor mass was measured with a caliper and calculated as π/6 × length (mm) × width (mm)². c After 21 days of treatment, the mice were sacrificed, and tumor sizes were measured. The average tumor sizes in each treatment group are presented as a bar histogram (right panel). Bar values are presented as mean ± SD. *P < 0.05. d The expression of MGMT, RAD51, and p-BRCA1 was analyzed in paraffin-embedded tumor sections obtained from mice in each treatment group through immnunohistochemical staining. The slides were then examined under a fluorescence microscope, and photomicrographs were taken at a magnification of ×400