Table 2.
Neuropsychiatric symptoms among cognitively intact DIAD mutation carriers and non-carriers
| DIAD mutation non-carriers (n = 102) | DIAD mutation carriers (n = 119) | p value | |
|---|---|---|---|
| NPI-Q Score | 0.64 (1.23) | 0.88 (2.19) | 0.338 |
| NPI-Q Sub-scale | |||
| Agitation | 0.07 (0.29) | 0.08 (0.40) | 0.699 |
| Anxiety | 0.10 (0.35) | 0.11 (0.33) | 0.856 |
| Apathy | 0.01 (0.09) | 0.04 (0.27) | 0.295 |
| Appetite | 0.10 (0.41) | 0.10 (0.39) | 0.525 |
| Delusion | 0.00 (0.00) | 0.01 (0.09) | – |
| Depression | 0.13 (0.43) | 0.13 (0.46) | 0.748 |
| Disinhibition | 0.01 (0.09) | 0.03 (0.27) | 0.609 |
| Elation | 0.02 (0.13) | 0.00 (0.00) | 0.055 |
| Hallucination | 0.00 (0.00) | 0.00 (0.00) | – |
| Irritability | 0.12 (0.40) | 0.18 (0.56) | 0.207 |
| Motor | 0.02 (0.19) | 0.05 (0.28) | 0.366 |
| Sleep changes | 0.07 (0.35) | 0.14 (0.47) | 0.195 |
Mixed Model with family-level random-effects, corrected for age, gender, APOE, education and family mutation type
NPI-Q neuropsychiatric inventory-questionnaire