Table 5.
Neuropsychiatric symptoms (Factors) among cognitively intact DIAD mutation carriers
| Regression estimate | 95% CI | p value | |
|---|---|---|---|
| Age | − 0.076 | − 0.016, − 0.002 | < 0.001 |
| EYO | − 0.070 | − 0.101, − 0.038 | < 0.001 |
| Factor 1 | Agitation + Disinhibition + Irritability + Depression | ||
| 0.010 | − 0.024, 0.022 | 0.367 | |
| Factor 2 | Anxiety + Apathy + Depression + Motor + Sleep changes | ||
| − 0.026 | − 0.049, − 0.004 | 0.023 | |
| Factor 3 | Delusion + Sleep changes + Irritability | ||
| 0.008 | − 0.014, 0.031 | 0.478 | |
| Factor 4 | Appetite + Anxiety | ||
| − 0.004 | − 0.020, 0.012 | 0.481 | |
| 2-Way Interactions | |||
| Factor 1 X EYO | − 0.044 | − 0.071, 0.017 | 0.001 |
| Factor 2 X EYO | − 0.020 | − 0.047, 0.007 | 0.140 |
| Factor 3 X EYO | 0.006 | − 0.020, 0.033 | 0.637 |
| Factor 4 X EYO | − 0.005 | − 0.026, 0.016 | 0.649 |
Mixed Model with family-level random-effects, corrected for 2-way interactions of Factors (1 to 4) X age, 3-way interactions Factors (1 to 4) X Age X EYO, gender, APOE, education and family mutation type