Table 3.
T-tau and p-tau subgroup comparisons on baseline characteristics
| Biomarker: platform | Cohort | Characteristic | Cognitive state | Subgroup 1 | Subgroup 2 | Subgroup 3 | Subgroup 4 | p value 1 vs 2 | p value 1 vs 3 | p value 1 vs 4 | p value 2 vs 3 | p value 2 vs 4 | p value 3 vs 4 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T-tau: Innotest | ADC | N | All | 1043 | 859 | 632 | 93 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. |
| T-tau pg/ml cutoffs | All | ≤ 349 | 350–671 | 672–1380 | > 1380 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| N (%) | NC | 576 (78%) | 135 (18%) | 24 (3%) | 5 (1%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| MCI | 262 (44%) | 207 (35%) | 118 (20%) | 4 (1%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| AD dementia | 205 (16%) | 517 (40%) | 490 (38%) | 84 (6%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| Abnormal ab42, n (%) | NC | 57 (9.9%) | 47 (34.8%) | 16 (66.7%) | 4 (80%) | 2.71E−12 | 6.49E−15 | 7.84E−05 | 4.00E−02 | 6.73E−01 | 9.90E−01 | ||
| MCI | 74 (28.2%) | 140 (67.6%) | 108 (91.5%) | 4 (100%) | 2.45E−16 | 6.64E−29 | 6.01E−02 | 1.31E−05 | 9.90E−01 | 9.90E−01 | |||
| AD dementia | 146 (71.2%) | 472 (91.3%) | 474 (96.7%) | 81 (96.4%) | 5.86E−11 | 1.08E−21 | 2.76E−05 | 2.96E−03 | 9.83E−01 | 9.90E−01 | |||
| MMSE, mean ± SD | NC | 28.2 ± 1.8 | 28.2 ± 1.6 | 27.4 ± 2.1 | 27.8 ± 1.9 | 1.00E+00 | 1.34E−01 | 9.65E−01 | 1.61E−01 | 9.62E−01 | 9.62E−01 | ||
| MCI | 26.7 ± 2.4 | 26.6 ± 2.2 | 25.9 ± 2.8 | 25.2 ± 2.6 | 9.85E−01 | 2.53E−02 | 6.41E−01 | 7.27E−02 | 6.84E−01 | 9.47E−01 | |||
| AD dementia | 21.3 ± 4.6 | 20.8 ± 5 | 20.2 ± 5.1 | 18.8 ± 5.1 | 5.53E−01 | 3.94E−02 | 7.13E−04 | 2.82E−01 | 5.16E−03 | 8.41E−02 | |||
| Age, mean ± SD | NC | 58.2 ± 8.5 | 64.2 ± 8 | 66.1 ± 9.7 | 65.8 ± 11.7 | 0.00E+00 | 4.83E−05 | 1.86E−01 | 7.42E−01 | 9.75E−01 | 1.00E+00 | ||
| MCI | 64 ± 8.4 | 67.9 ± 7.6 | 69.1 ± 7.1 | 69.9 ± 12 | 1.24E−06 | 5.96E−08 | 4.54E−01 | 5.28E−01 | 9.58E−01 | 9.97E−01 | |||
| AD dementia | 66.5 ± 8 | 66.5 ± 7.9 | 65.7 ± 8.3 | 65.7 ± 8.1 | 1.00E+00 | 6.10E−01 | 8.52E−01 | 3.68E−01 | 8.11E−01 | 1.00E+00 | |||
| Female, n (%) | NC | 234 (40.6%) | 57 (42.2%) | 11 (45.8%) | 4 (80%) | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | ||
| MCI | 65 (24.8%) | 83 (40.1%) | 67 (56.8%) | 2 (50%) | 3.53E−03 | 1.71E−08 | 9.90E−01 | 3.21E−02 | 9.90E−01 | 9.90E−01 | |||
| AD dementia | 81 (39.5%) | 263 (50.9%) | 277 (56.5%) | 53 (63.1%) | 4.51E−02 | 3.63E−04 | 2.58E−03 | 4.94E−01 | 2.98E−01 | 9.90E−01 | |||
| APOE e4 carrier, n (%) | NC | 183 (33.1%) | 58 (45%) | 15 (62.5%) | 2 (40%) | 8.88E−02 | 3.56E−02 | 9.90E−01 | 1.00E+00 | 9.90E−01 | 9.90E−01 | ||
| MCI | 92 (36.9%) | 115 (59.6%) | 77 (75.5%) | 3 (75%) | 2.15E−05 | 6.98E−10 | 9.90E−01 | 5.64E−02 | 1.00E+00 | 9.90E−01 | |||
| AD dementia | 113 (58.9%) | 313 (65.3%) | 310 (67.5%) | 55 (67.1%) | 8.18E−01 | 2.55E−01 | 9.90E−01 | 1.00E+00 | 1.00E+00 | 9.90E−01 | |||
| T-tau: Luminex | ADNI | N | All | 335 | 468 | 310 | 108 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. |
| T-tau pg/ml cutoffs | All | ≤ 54 | 55–95 | 96–171 | > 171 s | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| N (%) | NC | 154 (42%) | 151 (41%) | 63 (17%) | 3 (1%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| MCI | 168 (27%) | 249 (40%) | 146 (23%) | 59 (9%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| AD dementia | 13 (6%) | 68 (30%) | 101 (44%) | 46 (20%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| Abnormal ab42, n (%) | NC | 54 (35.1%) | 55 (36.4%) | 45 (71.4%) | 2 (66.7%) | 9.90E−01 | 1.34E−05 | 9.90E−01 | 3.58E−05 | 9.90E−01 | 9.90E−01 | ||
| MCI | 53 (31.5%) | 155 (62.2%) | 138 (94.5%) | 57 (96.6%) | 8.68E−09 | 9.22E−29 | 1.73E−16 | 2.12E−11 | 4.08E−06 | 9.90E−01 | |||
| AD dementia | 9 (69.2%) | 59 (86.8%) | 97 (96%) | 45 (97.8%) | 9.90E−01 | 1.70E−02 | 4.10E−02 | 3.26E−01 | 5.23E−01 | 9.90E−01 | |||
| MMSE, mean ± SD | NC | 29.1 ± 1.2 | 29 ± 1 | 29.1 ± 1.4 | 29 ± 1 | 9.87E−01 | 1.00E+00 | 1.00E+00 | 9.97E−01 | 1.00E+00 | 1.00E+00 | ||
| MCI | 28.3 ± 1.6 | 27.8 ± 1.8 | 27.3 ± 1.8 | 26.8 ± 1.9 | 2.27E−02 | 1.41E−05 | 6.60E−07 | 7.24E−02 | 1.66E−03 | 2.86E−01 | |||
| AD dementia | 24.4 ± 1.3 | 23.6 ± 2 | 23 ± 2 | 23.3 ± 2 | 5.75E−01 | 1.02E−01 | 2.87E−01 | 2.60E−01 | 8.11E−01 | 9.11E−01 | |||
| Age, mean ± SD | NC | 72.5 ± 5.6 | 74 ± 5.8 | 76.3 ± 6.2 | 74.1 ± 3.4 | 9.69E−02 | 5.53E−05 | 9.64E−01 | 3.49E−02 | 1.00E+00 | 9.10E−01 | ||
| MCI | 70.7 ± 7.5 | 72.6 ± 7.6 | 73.7 ± 7.4 | 73.3 ± 7 | 5.69E−02 | 2.46E−03 | 1.15E−01 | 4.89E−01 | 9.34E−01 | 9.78E−01 | |||
| AD dementia | 78.4 ± 6.6 | 75.6 ± 8.7 | 75.1 ± 7.5 | 72.2 ± 8.6 | 6.66E−01 | 4.98E−01 | 6.62E−02 | 9.72E−01 | 1.08E−01 | 1.73E−01 | |||
| Female, n (%) | NC | 81 (52.6%) | 78 (51.7%) | 33 (52.4%) | 3 (100%) | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | ||
| MCI | 68 (40.5%) | 89 (35.7%) | 64 (43.8%) | 34 (57.6%) | 1.00E+00 | 9.90E−01 | 2.01E−01 | 8.23E−01 | 1.98E−02 | 6.12E−01 | |||
| AD dementia | 3 (23.1%) | 18 (26.5%) | 45 (44.6%) | 29 (63%) | 1.00E+00 | 9.90E−01 | 1.51E−01 | 1.58E−01 | 1.30E−03 | 3.44E−01 | |||
| APOE e4 carrier, n (%) | NC | 32 (20.8%) | 44 (29.1%) | 26 (41.3%) | 1 (33.3%) | 7.19E−01 | 2.05E−02 | 9.90E−01 | 7.07E−01 | 1.00E+00 | 9.90E−01 | ||
| MCI | 43 (25.6%) | 117 (47%) | 103 (70.5%) | 44 (74.6%) | 1.01E−04 | 2.45E−14 | 4.77E−10 | 5.27E−05 | 1.46E−03 | 9.90E−01 | |||
| AD dementia | 7 (53.8%) | 43 (63.2%) | 75 (74.3%) | 29 (63%) | 9.90E−01 | 9.90E−01 | 1.00E+00 | 9.90E−01 | 9.90E−01 | 9.90E−01 | |||
| T-tau: Elecsys | ADNI | N | All | 291 | 495 | 332 | 75 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. |
| T-tau pg/ml cutoffs | All | ≤ 192 | 193–311 | 312–514 | > 514 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| N (%) | NC | 126 (35%) | 164 (45%) | 69 (19%) | 4 (1%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| MCI | 152 (25%) | 258 (42%) | 157 (26%) | 41 (7%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| AD dementia | 13 (6%) | 73 (33%) | 106 (48%) | 30 (14%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| Abnormal ab42, n (%) | NC | 40 (31.7%) | 67 (40.9%) | 40 (58%) | 3 (75%) | 8.49E−01 | 3.93E−03 | 9.90E−01 | 1.47E−01 | 9.90E−01 | 9.90E−01 | ||
| MCI | 52 (34.2%) | 153 (59.3%) | 146 (93%) | 40 (97.6%) | 9.25E−06 | 1.06E−25 | 1.23E−11 | 1.67E−12 | 2.77E−05 | 9.90E−01 | |||
| AD dementia | 8 (61.5%) | 67 (91.8%) | 100 (94.3%) | 29 (96.7%) | 6.33E−02 | 4.91E−03 | 6.03E−02 | 9.90E−01 | 9.90E−01 | 9.90E−01 | |||
| MMSE, mean ± SD | NC | 29.2 ± 1.1 | 29 ± 1.1 | 29 ± 1.4 | 29.2 ± 1 | 5.42E−01 | 8.40E−01 | 9.99E−01 | 9.95E−01 | 9.66E−01 | 9.79E−01 | ||
| MCI | 28.1 ± 1.7 | 27.9 ± 1.8 | 27.2 ± 1.8 | 27.1 ± 1.8 | 6.43E−01 | 1.70E−05 | 6.98E−03 | 2.46E−04 | 3.86E−02 | 9.98E−01 | |||
| AD dementia | 24.5 ± 1.5 | 23.5 ± 1.9 | 23 ± 2.1 | 23.5 ± 1.9 | 3.88E−01 | 7.21E−02 | 4.57E−01 | 3.92E−01 | 1.00E+00 | 6.83E−01 | |||
| Age, mean ± SD | NC | 71.6 ± 5.5 | 74.4 ± 5.8 | 76.1 ± 6.2 | 76.7 ± 6 | 3.60E−04 | 1.86E−06 | 2.95E−01 | 1.56E−01 | 8.47E−01 | 9.96E−01 | ||
| MCI | 70.9 ± 7.9 | 72.4 ± 7.4 | 73.9 ± 7.4 | 71.7 ± 6.9 | 2.02E−01 | 3.72E−03 | 9.26E−01 | 2.48E−01 | 9.47E−01 | 3.81E−01 | |||
| AD dementia | 77.7 ± 7.3 | 75.6 ± 8.1 | 74.3 ± 8.1 | 73.5 ± 8.7 | 8.13E−01 | 4.81E−01 | 4.09E−01 | 7.40E−01 | 6.61E−01 | 9.69E−01 | |||
| Female, n (%) | NC | 69 (54.8%) | 80 (48.8%) | 37 (53.6%) | 4 (100%) | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | 7.74E−01 | 9.90E−01 | ||
| MCI | 55 (36.2%) | 99 (38.4%) | 72 (45.9%) | 23 (56.1%) | 9.90E−01 | 6.41E−01 | 2.01E−01 | 9.69E−01 | 2.90E−01 | 9.90E−01 | |||
| AD dementia | 3 (23.1%) | 23 (31.5%) | 51 (48.1%) | 17 (56.7%) | 9.90E−01 | 9.40E−01 | 5.40E−01 | 2.35E−01 | 1.86E−01 | 9.90E−01 | |||
| APOE e4 carrier, n (%) | NC | 26 (20.6%) | 45 (27.4%) | 29 (42%) | 1 (25%) | 9.90E−01 | 1.58E−02 | 1.00E+00 | 2.54E−01 | 9.90E−01 | 9.90E−01 | ||
| MCI | 41 (27%) | 120 (46.5%) | 105 (66.9%) | 32 (78%) | 8.40E−04 | 2.90E−11 | 3.90E−08 | 4.95E−04 | 2.03E−03 | 9.90E−01 | |||
| AD dementia | 5 (38.5%) | 51 (69.9%) | 75 (70.8%) | 19 (63.3%) | 3.67E−01 | 2.55E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | |||
| P-tau: Innotest | ADC | N | All | 1106 | 953 | 490 | 78 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. |
| P-tau pg/ml cutoffs | All | ≤ 56 | 57–96 | 97–159 | > 159 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| N (%) | NC | 564 (76%) | 153 (21%) | 19 (3%) | 4 (1%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| MCI | 272 (46%) | 214 (36%) | 98 (17%) | 7 (1%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| AD dementia | 270 (21%) | 586 (45%) | 373 (29%) | 67 (5%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| Abnormal ab42, n (%) | NC | 61 (10.8%) | 44 (28.8%) | 16 (84.2%) | 3 (75%) | 3.22E−07 | 2.14E−18 | 6.88E−03 | 3.57E−05 | 8.98E−01 | 9.90E−01 | ||
| MCI | 78 (28.7%) | 153 (71.5%) | 89 (90.8%) | 6 (85.7%) | 9.08E−20 | 6.37E−25 | 2.78E−02 | 1.57E−03 | 9.90E−01 | 9.90E−01 | |||
| AD dementia | 204 (75.6%) | 546 (93.2%) | 358 (96%) | 65 (97%) | 4.83E−12 | 2.03E−13 | 1.07E−03 | 5.59E−01 | 9.90E−01 | 9.90E−01 | |||
| MMSE, mean ± SD | NC | 28.2 ± 1.8 | 28.1 ± 1.6 | 27.9 ± 2.1 | 27.5 ± 1.7 | 9.99E−01 | 9.53E−01 | 8.79E−01 | 9.71E−01 | 8.94E−01 | 9.68E−01 | ||
| MCI | 26.7 ± 2.3 | 26.6 ± 2.4 | 25.7 ± 2.7 | 27.1 ± 2.1 | 9.88E−01 | 1.99E−03 | 9.60E−01 | 7.13E−03 | 9.40E−01 | 3.93E−01 | |||
| AD dementia | 20.9 ± 5 | 20.7 ± 4.9 | 20.3 ± 5.2 | 19 ± 4.8 | 9.11E−01 | 4.53E−01 | 2.98E−02 | 7.26E−01 | 5.43E−02 | 2.07E−01 | |||
| Age, mean ± SD | NC | 58.3 ± 8.6 | 63.1 ± 8.3 | 67.1 ± 6.5 | 68.3 ± 16.8 | 7.58E−09 | 7.08E−05 | 9.30E−02 | 2.07E−01 | 6.19E−01 | 9.94E−01 | ||
| MCI | 64.1 ± 8.2 | 68 ± 7.9 | 69.3 ± 6.8 | 70.2 ± 10.1 | 3.55E−07 | 1.67E−07 | 1.77E−01 | 5.48E−01 | 8.89E−01 | 9.91E−01 | |||
| AD dementia | 66.7 ± 7.8 | 66.1 ± 8.1 | 65.6 ± 8 | 67.4 ± 9.2 | 7.76E−01 | 3.62E−01 | 9.13E−01 | 8.01E−01 | 6.02E−01 | 3.47E−01 | |||
| Female, n (%) | NC | 228 (40.4%) | 67 (43.8%) | 9 (47.4%) | 2 (50%) | 9.90E−01 | 1.00E+00 | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | ||
| MCI | 73 (26.8%) | 85 (39.7%) | 54 (55.1%) | 5 (71.4%) | 2.15E−02 | 4.97E−06 | 1.80E−01 | 9.45E−02 | 9.90E−01 | 9.90E−01 | |||
| AD dementia | 118 (43.7%) | 302 (51.5%) | 215 (57.6%) | 39 (58.2%) | 2.38E−01 | 3.89E−03 | 2.77E−01 | 4.48E−01 | 9.90E−01 | 9.90E−01 | |||
| APOE e4 carrier, n (%) | NC | 181 (33.3%) | 62 (43.1%) | 14 (73.7%) | 1 (25%) | 2.22E−01 | 4.13E−03 | 9.90E−01 | 1.39E−01 | 9.90E−01 | 9.90E−01 | ||
| MCI | 90 (35%) | 133 (66.2%) | 60 (71.4%) | 4 (66.7%) | 4.10E−10 | 6.79E−08 | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | |||
| AD dementia | 148 (59.2%) | 367 (66.6%) | 228 (65.7%) | 48 (75%) | 3.09E−01 | 7.44E−01 | 1.74E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | |||
| P-tau: Luminex | ADNI | N | All | 329 | 538 | 316 | 30 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. |
| P-tau pg/ml cutoffs | All | ≤ 23 | 24–46 | 47–99 | > 99 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| N (%) | NC | 138 (37%) | 166 (45%) | 62 (17%) | 3 (1%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| MCI | 173 (28%) | 266 (43%) | 166 (27%) | 13 (2%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| AD dementia | 18 (8%) | 106 (47%) | 88 (39%) | 14 (6%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| Abnormal ab42, n (%) | NC | 41 (29.7%) | 66 (39.8%) | 44 (71%) | 3 (100%) | 5.28E−01 | 6.79E−07 | 2.93E−01 | 3.11E−04 | 7.84E−01 | 9.90E−01 | ||
| MCI | 47 (27.2%) | 184 (69.2%) | 155 (93.4%) | 13 (100%) | 9.96E−17 | 4.99E−34 | 1.93E−06 | 3.28E−08 | 2.30E−01 | 9.90E−01 | |||
| AD dementia | 11 (61.1%) | 98 (92.5%) | 85 (96.6%) | 14 (100%) | 4.36E−03 | 1.28E−04 | 1.63E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | |||
| MMSE, mean ± SD | NC | 29.1 ± 1.2 | 29 ± 1.2 | 29.1 ± 1 | 30 ± 0 | 9.35E−01 | 1.00E+00 | 5.35E−01 | 9.83E−01 | 4.60E−01 | 5.32E−01 | ||
| MCI | 28.2 ± 1.6 | 27.5 ± 1.9 | 27.5 ± 1.8 | 27 ± 1.5 | 2.41E−04 | 1.71E−03 | 7.75E−02 | 1.00E+00 | 7.42E−01 | 7.33E−01 | |||
| AD dementia | 23.6 ± 1.9 | 23.3 ± 2 | 23.3 ± 2.1 | 23.6 ± 1.8 | 9.56E−01 | 9.15E−01 | 1.00E+00 | 9.94E−01 | 9.80E−01 | 9.55E−01 | |||
| Age, mean ± SD | NC | 73 ± 5.3 | 73.7 ± 6.5 | 75.4 ± 5.6 | 72.8 ± 2.5 | 7.76E−01 | 4.23E−02 | 1.00E+00 | 1.98E−01 | 9.94E−01 | 8.74E−01 | ||
| MCI | 71.7 ± 7.7 | 73 ± 7.8 | 72.6 ± 6.9 | 69.2 ± 7.8 | 2.58E−01 | 6.72E−01 | 6.78E−01 | 9.41E−01 | 2.92E−01 | 4.12E−01 | |||
| AD dementia | 80.6 ± 7.8 | 76 ± 7.4 | 72.9 ± 8.5 | 72.4 ± 5.3 | 9.87E−02 | 9.25E−04 | 1.76E−02 | 2.83E−02 | 3.57E−01 | 9.96E−01 | |||
| Female, n (%) | NC | 69 (50%) | 88 (53%) | 33 (53.2%) | 3 (100%) | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | ||
| MCI | 65 (37.6%) | 108 (40.6%) | 73 (44%) | 8 (61.5%) | 9.90E−01 | 9.90E−01 | 9.47E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | |||
| AD dementia | 4 (22.2%) | 43 (40.6%) | 36 (40.9%) | 10 (71.4%) | 9.90E−01 | 9.90E−01 | 9.20E−02 | 9.90E−01 | 3.45E−01 | 3.92E−01 | |||
| APOE e4 carrier, n (%) | NC | 28 (20.3%) | 43 (25.9%) | 29 (46.8%) | 2 (66.7%) | 9.90E−01 | 1.47E−03 | 9.90E−01 | 2.57E−02 | 9.90E−01 | 9.90E−01 | ||
| MCI | 49 (28.3%) | 132 (49.6%) | 115 (69.3%) | 10 (76.9%) | 8.90E−05 | 6.32E−13 | 5.36E−03 | 5.41E−04 | 6.08E−01 | 9.90E−01 | |||
| AD dementia | 7 (38.9%) | 73 (68.9%) | 61 (69.3%) | 12 (85.7%) | 1.71E−01 | 1.74E−01 | 1.24E−01 | 9.90E−01 | 9.90E−01 | 9.90E−01 | |||
| P-tau: Elecsys | ADNI | N | All | 467 | 454 | 199 | 63 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. |
| P-tau pg/ml cutoffs | All | ≤ 21 | 22–36 | 37–55 | > 55 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| N (%) | NC | 208 (57%) | 127 (35%) | 24 (7%) | 3 (1%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | ||
| MCI | 241 (40%) | 229 (38%) | 105 (17%) | 33 (5%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| AD dementia | 27 (12%) | 98 (44%) | 70 (32%) | 27 (12%) | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | |||
| Abnormal ab42, n (%) | NC | 63 (30.3%) | 61 (48%) | 23 (95.8%) | 2 (66.7%) | 9.91E−03 | 7.59E−09 | 1.00E+00 | 2.49E−04 | 1.00E+00 | 1.00E+00 | ||
| MCI | 83 (34.4%) | 173 (75.5%) | 102 (97.1%) | 33 (100%) | 5.17E−18 | 1.25E−25 | 2.03E−11 | 1.99E−05 | 1.75E−02 | 1.00E+00 | |||
| AD dementia | 18 (66.7%) | 92 (93.9%) | 68 (97.1%) | 26 (96.3%) | 2.61E−03 | 6.13E−04 | 8.52E−02 | 1.00E+00 | 1.00E+00 | 1.00E+00 | |||
| MMSE, mean ± SD | NC | 29.1 ± 1.2 | 28.9 ± 1.2 | 29.5 ± 0.8 | 29 ± 1 | 9.35E−01 | 1.00E+00 | 5.35E−01 | 9.83E−01 | 4.60E−01 | 5.32E−01 | ||
| MCI | 28.1 ± 1.7 | 27.7 ± 1.8 | 27.2 ± 1.8 | 26.9 ± 1.9 | 2.41E−04 | 1.71E−03 | 7.75E−02 | 1.00E+00 | 7.42E−01 | 7.33E−01 | |||
| AD dementia | 24 ± 1.7 | 23.3 ± 2 | 23 ± 2.1 | 23.6 ± 1.8 | 9.56E−01 | 9.15E−01 | 1.00E+00 | 9.94E−01 | 9.80E−01 | 9.55E−01 | |||
| Age, mean ± SD | NC | 72.5 ± 5.5 | 75.2 ± 6.3 | 77.3 ± 5.5 | 74.1 ± 3.4 | 7.76E−01 | 4.23E−02 | 1.00E+00 | 1.98E−01 | 9.94E−01 | 8.74E−01 | ||
| MCI | 70.9 ± 7.6 | 73.4 ± 7.6 | 73.4 ± 7.3 | 72.6 ± 7.1 | 2.58E−01 | 6.72E−01 | 6.78E−01 | 9.41E−01 | 2.92E−01 | 4.12E−01 | |||
| AD dementia | 78.1 ± 7.7 | 75.2 ± 7.7 | 73.8 ± 8.4 | 72.9 ± 8.7 | 9.87E−02 | 9.25E−04 | 1.76E−02 | 2.83E−02 | 3.57E−01 | 9.96E−01 | |||
| Female, n (%) | NC | 101 (48.6%) | 75 (59.1%) | 11 (45.8%) | 3 (100%) | 4.77E−01 | 1.00E+00 | 1.00E+00 | 1.00E+00 | 1.00E+00 | 1.00E+00 | ||
| MCI | 94 (39%) | 89 (38.9%) | 46 (43.8%) | 20 (60.6%) | 1.00E+00 | 1.00E+00 | 1.79E−01 | 1.00E+00 | 1.76E−01 | 8.25E−01 | |||
| AD dementia | 7 (25.9%) | 35 (35.7%) | 37 (52.9%) | 15 (55.6%) | 1.00E+00 | 1.84E−01 | 3.15E−01 | 2.39E−01 | 6.04E−01 | 1.00E+00 | |||
| APOE e4 carrier, n (%) | NC | 45 (21.6%) | 41 (32.3%) | 14 (58.3%) | 1 (33.3%) | 2.51E−01 | 1.50E−03 | 1.00E−03 | 1.66E−01 | 1.00E+00 | 1.00E+00 | ||
| MCI | 72 (29.9%) | 122 (53.3%) | 79 (75.2%) | 25 (75.8%) | 2.56E−06 | 7.89E−14 | 3.92E−06 | 1.36E−03 | 1.48E−01 | 1.00E+00 | |||
| AD dementia | 10 (37%) | 72 (73.5%) | 52 (74.3%) | 16 (59.3%) | 5.81E−03 | 8.60E−03 | 1.00E+00 | 1.00E−03 | 1.00E+00 | 1.00E+00 |
All pairwise comparisons are Tukey HSD adjusted for multiple testing
n.t. not tested