Table 4.

Sensitivity and specificity for clinical comparisons

			NC vs AD-type dementia				NC vs MCI
			First cut-point		Cut-point (literature)		First cut-point		Cut-point (literature)
Dataset	First cut-point	Cut-point (literature)	Sensitivity	Specificity	Sensitivity	Specificity	Sensitivity	Specificity	Sensitivity	Specificity
T-tau
ADC: Innotest	349	375a	0.84 (0.8–0.86)	0.78 (0.74–0.82)	0.81 (0.78–0.84)	0.82 (0.78–0.86)	0.56 (0.52–0.6)	0.78 (0.75–0.81)	0.52 (0.47–0.56)	0.82 (0.79–0.84)
ADNI: Luminex	54	93b	0.95 (0.9–0.98)	0.4 (0.33–0.48)	0.64 (0.55–0.72)	0.81 (0.74–0.86)	0.73 (0.69–0.76)	0.42 (0.36–0.47)	0.35 (0.31–0.39)	0.81 (0.76–0.84)
ADNI: Elecsys	192	300c	0.94 (0.88–0.97)	0.33 (0.26–0.4)	0.64 (0.55–0.72)	0.78 (0.71–0.84)	0.76 (0.72–0.79)	0.34 (0.29–0.39)	0.37 (0.33–0.4)	0.77 (0.72–0.81)
P-tau
ADC: Innotest	56	52a	0.78 (0.75–0.81)	0.77 (0.72–0.81)	0.83 (0.8–0.86)	0.72 (0.68–0.77)	0.54 (0.5–0.58)	0.76 (0.73–0.79)	0.59 (0.55–0.63)	0.7 (0.67–0.73)
ADNI: Luminex	23	23b	0.9 (0.84–0.95)	0.4 (0.33–0.47)	0.9 (0.84–0.95)	0.4 (0.33–0.48)	0.72 (0.68–0.76)	0.37 (0.32–0.42)	0.72 (0.68–0.76)	0.37 (0.32–0.43)
ADNI: Elecsys	21	24c	0.84 (0.76–0.9)	0.56 (0.48–0.63)	0.8 (0.72–0.87)	0.67 (0.6–0.74)	0.61 (0.57–0.65)	0.56 (0.51–0.61)	0.5 (0.46–0.54)	0.68 (0.63–0.72)

MCI mild cognitive impairment, NC normal cognition

^aSource: [5]

^bSource: [21]

^cSource: [23]