Table 8.

T-tau and p-tau subgroup comparisons on annual change in CSF t-tau and p-tau values

	Effect time			Interaction subgroup x time		Annual change (se) for each subgroup				p values pairwise comparisons in slope differences between subgroups						Baseline effect tau group		Baseline estimated marginal means (SE) for each subgroup				p values pairwise comparisons in baseline estimates between subgroups
Biomarker: platform	F	p value		F	p value	Subgroup 1	Subgroup 2	Subgroup 3	Subgroup 4	1 vs 2	1 vs 3	1 vs 4	2 vs 3	2 vs 4	3 vs 4	F	p value	Subgroup 1	Subgroup 2	Subgroup 3	Subgroup 4	1 vs 2	1 vs 3	1 vs 4	2 vs 3	2 vs 4	3 vs 4
T-tau: Luminex	14	1.74E−04		0.2	8.96E−01	1.72 (0.75) a	2.03 (0.57) c	2.2 (0.71) b	1.08 (1.44)	7.45E−01	6.43E−01	6.94E−01	8.50E−01	5.41E−01	4.86E−01	1318	7.48E−273	44.6 (1.89)	76.4 (1.43)	129.3 (1.73)	221.9 (3.24)	1.65E−36	1.83E−137	6.43E−206	1.68E−87	3.96E−177	3.88E−96
T-tau: Elecsys	37	2.55E−09		2.5	5.98E−02	3.34 (1.68) a	4.8 (1.16) c	8.71 (1.46) c	8.36 (3.31) a	4.74E−01	1.62E−02	1.77E−01	3.67E−02	3.11E−01	9.23E−01	1330	1.30E−261	162.4 (4.49)	254.1 (3.05)	392.8 (3.64)	616.8 (7.86)	7.82E−53	1.58E−168	1.28E−215	7.20E−117	1.89E−184	4.47E−99
P-tau: Luminex	2	1.63E−01		15	2.93E−09	3.17 (0.72) c	4.67 (0.6) c	2.89 (0.88) b	−15.23 (2.95) c	1.11E−01	8.07E−01	2.58E−09	9.58E−02	8.98E−11	6.95E−09	808	6.11E−222	21.8 (1.06)	39.1 (0.84)	65.5 (1.22)	109.5 (3.99)	9.63E−33	2.98E−101	1.14E−73	5.97E−56	9.88E−54	7.98E−24
P-tau: Elecsys	0.005	2.85E−02		1.5	2.13E−01	0.26 (0.13)a	0.48 (0.13) c	0.49 (0.21) a	−0.22 (0.37)	2.12E−01	3.28E−01	2.25E−01	9.68E−01	7.35E−02	9.28E−02	1456	3.10E−270	16.8 (0.36)	28.4 (0.34)	43.4 (0.52)	66.0 (0.90)	1.96E−181	7.62E−221	7.62E−221	1.64E−90	1.76E−167	6.98E−78

CSF t- and p-tau values are in pg/ml. Baseline effects are reported in the last columns. Bold font highlights significant effects. Slope that differs from 0 is indicated with ^a when p < .05, ^b when p < .01 or ^c when p < .001

SE standard error