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Development and functions of CD169+ macrophages.
| Organ | Development | Area | Functions |
|---|---|---|---|
| Lymph nodes | LT-α and LT-β | SS | Low phagocytic, present antigens, secrete cytokines |
| Medulla | Engulf and present microbial antigens | ||
| Spleen | LT-α and LT-β | Marginal zone | Engulf and present viruses and apoptotic cell antigens, antiviral effects, immune tolerance |
| Colon | Vitamin A | Lamina propria | Present antigens, secrete CCL8, recruit monocytes, promote inflammation |
LT: lymphotoxin; SS: subcapsular sinus.
